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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Pbsn-Ar*E231G)7353Ng
transgene insertion 7353, Norman M Greenberg
MGI:3831171
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Pbsn-Ar*E231G)7353Ng/0 involves: FVB/N MGI:3831195


Genotype
MGI:3831195
tg1
Allelic
Composition
Tg(Pbsn-Ar*E231G)7353Ng/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pbsn-Ar*E231G)7353Ng mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• at 1 year all males show primary prostate tumors with associated lymphocytic invasion
• metastatic deposits are detected in lungs of all mice and 50 weeks

endocrine/exocrine glands
• epithelial hyperplasia and dysplasia are observed in ventral lobe of prostate in all mice at 12 weeks; lesions present as disorganized layers of epithelial cells in contrast to single regular layer observed in controls
• tufting and intraepithelial lumen formation, cellular atypia with enlarged, hyperchromatic nuclei of variable shapes and sizes are frequently observed
• epithelial hyperplasia and dysplasia are observed in ventral lobe of prostate in all mice at 12 weeks
• at 1 year all males show primary prostate tumors with associated lymphocytic invasion

reproductive system
• epithelial hyperplasia and dysplasia are observed in ventral lobe of prostate in all mice at 12 weeks; lesions present as disorganized layers of epithelial cells in contrast to single regular layer observed in controls
• tufting and intraepithelial lumen formation, cellular atypia with enlarged, hyperchromatic nuclei of variable shapes and sizes are frequently observed
• epithelial hyperplasia and dysplasia are observed in ventral lobe of prostate in all mice at 12 weeks
• at 1 year all males show primary prostate tumors with associated lymphocytic invasion





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory