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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tm7sf2tm1Fdp
targeted mutation 1, Forbes D Porter
MGI:3829354
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tm7sf2tm1Fdp/Tm7sf2tm1Fdp involves: 129S4/SvJae * C57BL/6 MGI:3829377
cx2
 		Lbric-J/Lbric-J
Tm7sf2tm1Fdp/Tm7sf2tm1Fdp 		involves: 129S4/SvJae * C57BL/6 MGI:3829378
cx3
 		Lbric-J/Lbric-J
Tm7sf2tm1Fdp/Tm7sf2+ 		involves: 129S4/SvJae * C57BL/6 MGI:3829379
cx4
 		Lbric-J/Lbr+
Tm7sf2tm1Fdp/Tm7sf2tm1Fdp 		involves: 129S4/SvJae * C57BL/6 MGI:3829381


Genotype
MGI:3829377
hm1
Allelic
Composition		 Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tm7sf2tm1Fdp mutation (0 available); any Tm7sf2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal homeostasis ( J:143838 )
• reduced sterol levels in the brain cortex

skeleton




Genotype
MGI:3829378
cx2
Allelic
Composition		 Lbric-J/Lbric-J
Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lbric-J mutation (1 available); any Lbr mutation (55 available)
Tm7sf2tm1Fdp mutation (0 available); any Tm7sf2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3829379
cx3
Allelic
Composition		 Lbric-J/Lbric-J
Tm7sf2tm1Fdp/Tm7sf2+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lbric-J mutation (1 available); any Lbr mutation (55 available)
Tm7sf2tm1Fdp mutation (0 available); any Tm7sf2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:143838 )
• die at varying times prenatally

craniofacial
cleft palate ( J:143838 )
• in four embryos recovered at birth

skeleton
fused phalanges ( J:143838 )
• in four embryos recovered at birth distal phalanges of the second and third digits are fused

hematopoietic system
extramedullary hematopoiesis ( J:143838 )
• decreased hepatic extramedullary hematopoiesis in four embryos recovered at birth

digestive/alimentary system
cleft palate ( J:143838 )
• in four embryos recovered at birth

limbs/digits/tail
fused phalanges ( J:143838 )
• in four embryos recovered at birth distal phalanges of the second and third digits are fused

growth/size/body
cleft palate ( J:143838 )
• in four embryos recovered at birth




Genotype
MGI:3829381
cx4
Allelic
Composition		 Lbric-J/Lbr+
Tm7sf2tm1Fdp/Tm7sf2tm1Fdp
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lbric-J mutation (1 available); any Lbr mutation (55 available)
Tm7sf2tm1Fdp mutation (0 available); any Tm7sf2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
postnatal growth retardation ( J:143838 )
• normal at birth
• impaired growth at 10 days

behavior/neurological
tremors ( J:143838 )
• by 10 days of age
ataxia ( J:143838 )
• by 10 days of age

nervous system
demyelination ( J:143838 )
• vacuolation and demyelination seen in the spinal cord

skeleton
abnormal skeleton development ( J:143838 )
• bone development is markedly abnormal
abnormal long bone epiphyseal plate proliferative zone ( J:143838 )
• noticeably shorter than normal, like those of a young adult
decreased width of hypertrophic chondrocyte zone ( J:143838 )
• noticeably shorter than normal, like those of a young adult

hematopoietic system
abnormal spleen morphology ( J:143838 )
• chromatin clumping in spleen cells seen by electron microscopy

homeostasis/metabolism
abnormal homeostasis ( J:143838 )
• marked reduction of sterol levels in the brain cortex

immune system
abnormal spleen morphology ( J:143838 )
• chromatin clumping in spleen cells seen by electron microscopy




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory