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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dock1tm1Jfco
targeted mutation 1, Jean-Francois Cote
MGI:3828065
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dock1tm1Jfco/Dock1tm1Jfco involves: 129 MGI:5301324
hm2
Dock1tm1Jfco/Dock1tm1Jfco involves: 129/Sv * C57BL/6 MGI:3828076
cx3
Dock1tm1Jfco/Dock1tm1Jfco
Dock5Gt(AN0268)Wtsi/Dock5Gt(AN0268)Wtsi
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:3828078
cx4
Dock1tm1Jfco/Dock1+
Dock5Gt(AN0268)Wtsi/Dock5Gt(AN0268)Wtsi
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:3828079
cx5
Dock1tm1Jfco/Dock1+
Dock5Gt(AN0268)Wtsi/Dock5+
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:3828080


Genotype
MGI:5301324
hm1
Allelic
Composition
Dock1tm1Jfco/Dock1tm1Jfco
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock1tm1Jfco mutation (0 available); any Dock1 mutation (91 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle

homeostasis/metabolism
• severe edema in a large area of the back at E14.5

cardiovascular system
• sometimes fused as well




Genotype
MGI:3828076
hm2
Allelic
Composition
Dock1tm1Jfco/Dock1tm1Jfco
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock1tm1Jfco mutation (0 available); any Dock1 mutation (91 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• although present in Mendelian ratios at E18.5, all mice die prior to weaning

muscle
• at E14.5, muscle mass and myoblast fusion are decreased compared to in wild-type mice
• in culture, myoblasts are unable to form long nucleated fibers after 4 days unlike wild-type cells
• however, myoblast differentiation and migration of muscle progenitors are normal
• at E12.5, E13.5 and E18.5, the diameter of muscle fibers is decreased compared to in wild-type mice
• at E14.5 and E16.5, the attachment of the diaphragm to the intercostal muscles is severely impaired
• at E14.5, and E16.5
• intercostal muscles are reduced in size leading to ribs stacked closer together than in wild-type mice
• at E16.5 and E18.5, the size of deep back muscles, tongue and limb muscles is reduced compared to in wild-type mice
• at E13.5, apoptosis of myofibers is increased compared to in wild-type mice

respiratory system
• lungs do not inflate

growth/size/body
• at birth, mice are smaller than normal and fail to straighten

homeostasis/metabolism
• within minutes of birth




Genotype
MGI:3828078
cx3
Allelic
Composition
Dock1tm1Jfco/Dock1tm1Jfco
Dock5Gt(AN0268)Wtsi/Dock5Gt(AN0268)Wtsi
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock1tm1Jfco mutation (0 available); any Dock1 mutation (91 available)
Dock5Gt(AN0268)Wtsi mutation (1 available); any Dock5 mutation (128 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• mice fail to undergo early embryogenesis and instead undergo necrosis




Genotype
MGI:3828079
cx4
Allelic
Composition
Dock1tm1Jfco/Dock1+
Dock5Gt(AN0268)Wtsi/Dock5Gt(AN0268)Wtsi
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock1tm1Jfco mutation (0 available); any Dock1 mutation (91 available)
Dock5Gt(AN0268)Wtsi mutation (1 available); any Dock5 mutation (128 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• mice exhibit variably thin myofibrils




Genotype
MGI:3828080
cx5
Allelic
Composition
Dock1tm1Jfco/Dock1+
Dock5Gt(AN0268)Wtsi/Dock5+
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock1tm1Jfco mutation (0 available); any Dock1 mutation (91 available)
Dock5Gt(AN0268)Wtsi mutation (1 available); any Dock5 mutation (128 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
N
• intercostal muscles develop normally





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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory