• at 14 to 16 weeks of age, mice exhibit 28% lower plasma magnesium levels than in wild-type mice

• plasma potassium levels are 17% lower than in wild-type mice

• at 14 to 16 weeks of age, absolute calcium excretion is 3-fold and fractional excretion is 4-fold higher than in wild-type mice

• at 14 to 16 weeks of age, absolute magnesium excretion is 2-fold and fractional excretion is 4-fold higher than in wild-type mice

• fractional excretion of potassium is 2-fold more than in wild-type mice

• at 14 to 16 weeks of age, absolute calcium excretion is 3-fold and fractional excretion is 4-fold higher than in wild-type mice

• at 14 to 16 weeks of age, absolute magnesium excretion is 2-fold and fractional excretion is 4-fold higher than in wild-type mice

• fractional excretion of potassium is 2-fold more than in wild-type mice

• at 6 months, mice exhibit calcium deposits in the basement membrane of the medullary tubules and the surrounding interstitium unlike in wild-type mice

• when fed a calcium poor diet, mice exhibit a decrease in bone mineral content compared to similarly treated wild-type mice

• however, mice exhibit normal bone mineral content on a standard diet

• when fed a calcium poor diet, mice exhibit a decrease in bone mineral density compared to similarly treated wild-type mice

• however, mice exhibit normal bone mineral density on a standard diet