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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(ACTA1-FRG1)medRotu
transgene insertion med, Rossella Tupler
MGI:3817487
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(ACTA1-FRG1)medRotu/0 C57BL/6-Tg(ACTA1-FRG1)medRotu MGI:3817493


Genotype
MGI:3817493
tg1
Allelic
Composition
Tg(ACTA1-FRG1)medRotu/0
Genetic
Background
C57BL/6-Tg(ACTA1-FRG1)medRotu
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• muscle fibers exhibit marked proliferation of collagen fibrils with histopathological signs of muscular dystrophy
• muscle fibers exhibit increased centrally localized nuclei
• total muscle weight is 75% of wild-type
• the severity of dystrophic muscles corresponds to expression levels of the transgene and results in reduced muscle mass
• however, mitochondrial activity and sarcolemmal integrity within muscle fibers are normal

homeostasis/metabolism
• mice exhibit reduced tolerance to exercise compared to wild-type mice

growth/size/body
• mice weigh 80% of wild-type

skeleton
• mice exhibit mild kyphosis
• however, mice exhibit normal spinal columns

behavior/neurological
N
• despite decreased weight, mice exhibit normal caloric intake
• mice exhibit reduced tolerance to exercise compared to wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Facioscapulohumeral Muscular Dystrophy 1; FSHD1 158900 J:106896





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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory