Phenotypes associated with this allele

• Allele Symbol: Edil3^tm1Tq
• Allele Name: targeted mutation 1, Thomas Quertermous
• Allele ID: MGI:3817261
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Edil3^tm1Tq/Edil3^tm1Tq	B6.129S6-Edil3^tm1Tq	MGI:3817275
hm2	Edil3^tm1Tq/Edil3^tm1Tq	involves: 129S6/SvEvTac * C57BL/6	MGI:6780040
cx3	Edil3^tm1Tq/Edil3^tm1Tq Itgal^tm1Bll/Itgal^tm1Bll	involves: 129 * C57BL/6	MGI:3817278

Genotype
MGI:3817275

hm1

• Allelic Composition: Edil3^tm1Tq/Edil3^tm1Tq
• Genetic Background: B6.129S6-Edil3^tm1Tq

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cellular extravasation ( J:141063 )

• mice display significantly higher accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice

abnormal leukocyte adhesion ( J:141063 )

• about twice as many leukocytes bind to mutant endothelial cells in vitro as compared to wild-type leukocytes

• mice have increased numbers of leukocytes adherent to postcapillary venules both in the baseline condition and upon TNF stimulation

enhanced leukocyte tethering or rolling ( J:141063 )

• a significant decrease in rolling velocity accompanied by an increase in the fraction of slow-rolling leukocytes is observed in postcapillary venules

abnormal neutrophil physiology ( J:141063 )

• enhanced neutrophil recruitment occurs in these mice with higher accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice

cellular

abnormal cellular extravasation ( J:141063 )

• mice display significantly higher accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice

abnormal leukocyte adhesion ( J:141063 )

• about twice as many leukocytes bind to mutant endothelial cells in vitro as compared to wild-type leukocytes

• mice have increased numbers of leukocytes adherent to postcapillary venules both in the baseline condition and upon TNF stimulation

enhanced leukocyte tethering or rolling ( J:141063 )

• a significant decrease in rolling velocity accompanied by an increase in the fraction of slow-rolling leukocytes is observed in postcapillary venules

hematopoietic system

abnormal cellular extravasation ( J:141063 )

• mice display significantly higher accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice

abnormal leukocyte adhesion ( J:141063 )

• about twice as many leukocytes bind to mutant endothelial cells in vitro as compared to wild-type leukocytes

• mice have increased numbers of leukocytes adherent to postcapillary venules both in the baseline condition and upon TNF stimulation

enhanced leukocyte tethering or rolling ( J:141063 )

• a significant decrease in rolling velocity accompanied by an increase in the fraction of slow-rolling leukocytes is observed in postcapillary venules

abnormal neutrophil physiology ( J:141063 )

• enhanced neutrophil recruitment occurs in these mice with higher accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice

Genotype
MGI:6780040

hm2

• Allelic Composition: Edil3^tm1Tq/Edil3^tm1Tq
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:299690 )

• near absence of new maxillar bone growth (bone regeneration) and persistence of deep periodontal pocket 5 days after end of 10-day periodontitis-inducing molar ligation

Genotype
MGI:3817278

cx3

• Allelic Composition: Edil3^tm1Tq/Edil3^tm1Tq; Itgal^tm1Bll/Itgal^tm1Bll
• Genetic Background: involves: 129 * C57BL/6

immune system

abnormal cellular extravasation ( J:141063 )

• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice

abnormal neutrophil physiology ( J:141063 )

• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice

cellular

abnormal cellular extravasation ( J:141063 )

• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice

hematopoietic system

abnormal cellular extravasation ( J:141063 )

• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice

abnormal neutrophil physiology ( J:141063 )

• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice