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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
thnh
thin hair
MGI:3815520
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
thnh/thnh NOD.Cg-H2b thnh/J MGI:3822331


Genotype
MGI:3822331
hm1
Allelic
Composition
thnh/thnh
Genetic
Background
NOD.Cg-H2b thnh/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
thnh mutation (1 available); any thnh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Abnormal hair follicle morphology of the thnh/thnh mouse

immune system
• at 3 weeks of age crowded follicles and skin inflammation are found
• at 4 weeks of age pieces of hair from broken down follicles are found free in the connective tissue and seem to cause severe foreign body granulomatous inflammation within giant cells

integument
• evident by 2 weeks of age
• all four hair types are present, but there are fewer zigzags than normal
• the follicles are somewhat dilated with the deepest portions of anagen hair follicles in the subcutaneous adipose layer degenerating
• at 3 weeks of age crowded follicles and skin inflammation are found
• at 4 weeks of age pieces of hair from broken down follicles are found free in the connective tissue and seem to cause severe foreign body granulomatous inflammation within giant cells





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory