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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(MT1A-Dyrk1a)#Xest
transgene insertion #, Xavier Estivill
MGI:3814575
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(MT1A-Dyrk1a)#Xest/0 involves: C57BL/6 * SJL MGI:3814581


Genotype
MGI:3814581
tg1
Allelic
Composition
Tg(MT1A-Dyrk1a)#Xest/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit retardation of development in a homing test with increased latency to reach the goal arena compared to wild-type mice
• mice spend more time than wild-type mice in the arms of an elevated plus maze and exhibit reduced emotionality
• in a wire suspension test, P14 mice exhibit a reduced latency to fall compared to wild-type mice (J:71821)
• in the coat hanger test, adult mice exhibit a reduced latency to fall compared to wild-type mice and the number of crossing along the bar was reduced compared to in wild-type mice (J:71821)
• mice perform poorly on a treadmill test (J:140647)
• however, treatment of mice with an adenovirus expressing a short hairpin RNA targeting Dyrk1a can rescue normal coordination (J:140647)
• in a pivoting test, mice exhibit more turnings at P10 than wild-type mice
• mice exhibit a delay in acquisition and maturation of locomotion from cranial to caudal parts of the body
• at P7, mice exhibit an increased latency to initiate walking compared to wild-type mice
• mice exhibit increased activity in the periphery and center of the arena in an open field test and in an elevated plus maze comapred to wild-type mice (J:71821)
• mice exhibit increased activity (J:140647)
• however, treatment of mice with an adenovirus expressing a short hairpin RNA targeting Dyrk1a can rescue normal activity levels (J:140647)
• mice exhibit a delay in maturation of gait and a persistence of immature locomotor patterns

nervous system
• mice exhibit a decrease in the paired pulse inhibition levels compared to wild type mice
• however, treatment of mice with an adenovirus expressing a short hairpin RNA targeting Dyrk1a can rescue normal paired pulse inhibition levels

Mouse Models of Human Disease
OMIM ID Ref(s)
Down Syndrome 190685 J:71821





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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory