Mouse Genome Informatics
tg1
    Tg(MT1A-Dyrk1a)#Xest/0
involves: C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• mice exhibit retardation of development in a homing test with increased latency to reach the goal arena compared to wild-type mice
• mice spend more time than wild-type mice in the arms of an elevated plus maze and exhibit reduced emotionality
• in a wire suspension test, P14 mice exhibit a reduced latency to fall compared to wild-type mice (J:71821)
• in the coat hanger test, adult mice exhibit a reduced latency to fall compared to wild-type mice and the number of crossing along the bar was reduced compared to in wild-type mice (J:71821)
• mice perform poorly on a treadmill test (J:140647)
• however, treatment of mice with an adenovirus expressing a short hairpin RNA targeting Dyrk1a can rescue normal coordination (J:140647)
• in a pivoting test, mice exhibit more turnings at P10 than wild-type mice
• mice exhibit a delay in acquisition and maturation of locomotion from cranial to caudal parts of the body
• at P7, mice exhibit an increased latency to initiate walking compared to wild-type mice
• mice exhibit increased activity in the periphery and center of the arena in an open field test and in an elevated plus maze comapred to wild-type mice (J:71821)
• mice exhibit increased activity (J:140647)
• however, treatment of mice with an adenovirus expressing a short hairpin RNA targeting Dyrk1a can rescue normal activity levels (J:140647)
• mice exhibit a delay in maturation of gait and a persistence of immature locomotor patterns

nervous system
• mice exhibit a decrease in the paired pulse inhibition levels compared to wild type mice
• however, treatment of mice with an adenovirus expressing a short hairpin RNA targeting Dyrk1a can rescue normal paired pulse inhibition levels

Mouse Models of Human Disease
OMIM IDRef(s)
Down Syndrome 190685 J:71821