Phenotypes associated with this allele

• Allele Symbol: Gnb3^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:3812642
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gnb3^tm1(KOMP)Vlcg/Gnb3^tm1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:5440450

Genotype
MGI:5440450

hm1

• Allelic Composition: Gnb3^{tm1(KOMP)Vlcg}/Gnb3^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:187720 )

• only 10% of mice are alive at 3 weeks of age

vision/eye

abnormal retina rod bipolar cell morphology ( J:187720 )

• rod bipolar dendrites are not maintained in the invagination of the rod termini

abnormal retina rod cell morphology ( J:187720 )

• abnormal rod synaptic tetrad

abnormal eye electrophysiology ( J:187720 )

• in an electroretinogram, mice lack clear positive-going (b) wave and the negative wave starts to rise soon after reaching its peak

• saturated (mixed) conditions, b wave is reduced compared to in wild-type mice

• 2 of 24 retinal cells give a small response to a strong light flash compared with 14 of 25 wild-type cells

• mice exhibit a greater reduction in con-driven b wave than rod-generated b wave

• however, mice exhibit normal negative (a) waves and residual b wave

abnormal cone electrophysiology ( J:187720 )

• saturated cone-generated negative ERG phase rises faster than the photopic a wave in Grm6^tm1Nak homozygotes

• however, mice exhibit normal response amplitudes under photopic conditions

abnormal rod electrophysiology ( J:187720 )

• for scotopic conditions, b wave is reduced compared to in wild-type mice

nervous system

abnormal retina rod bipolar cell morphology ( J:187720 )

• rod bipolar dendrites are not maintained in the invagination of the rod termini

abnormal retina rod cell morphology ( J:187720 )

• abnormal rod synaptic tetrad