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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sirt1tm1.1Cxd
targeted mutation 1.1, Chu-Xia Deng
MGI:3812143
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sirt1tm1.1Cxd/Sirt1tm1.1Cxd either: (involves: 129S6/SvEvTac * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * C57BL/6 * FVB/N) MGI:3812160
ht2
Sirt1tm1.1Cxd/Sirt1+ either: (involves: 129S6/SvEvTac * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * C57BL/6 * FVB/N) MGI:3812163
cx3
Sirt1tm1.1Cxd/Sirt1tm1.1Cxd
Trp53tm1Brd/Trp53tm1Brd
either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N) MGI:3812167
cx4
Sirt1tm1.1Cxd/Sirt1tm1.1Cxd
Trp53tm1Brd/Trp53+
either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N) MGI:3812169
cx5
Sirt1tm1.1Cxd/Sirt1+
Trp53tm1Brd/Trp53+
either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N) MGI:3812172


Genotype
MGI:3812160
hm1
Allelic
Composition
Sirt1tm1.1Cxd/Sirt1tm1.1Cxd
Genetic
Background
either: (involves: 129S6/SvEvTac * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * C57BL/6 * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt1tm1.1Cxd mutation (0 available); any Sirt1 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: the survival rate to adulthood on a 129S6/SvEv FVB background is 1% while the survival rate on a 129S6/SvEv FVB Black Swiss is 9.3%
• nearly all mice die between E14.5 and E16.5

cellular
• cells from E9.5 mice exhibit chromosomal abnormalities including aneuploidy, broken chromosomes and less condensed chromosomes
• heterochromatin formation is impaired
• in 37% of mouse embryo fibroblasts
• mouse embryonic fibroblasts exhibit reduced microhomologous DNA damage repair ability compared to in wild-type cells
• mouse embryonic fibroblasts exhibit defects in repair of UV irradiation damage
• however, less precise ligation and end joining is normal
• 37% of mouse embryo fibroblasts exhibit lagging chromosomes and unequal segregation during replication
• following treatment with low dose of gamma irradiation, mouse embryonic fibroblasts exhibit a defect in the G1/S checkpoint
• however, at high doses of radiation the G1/S checkpoint functions normally
• embryos exhibit an increase in the number of cells in the early phase of mitosis
• embryos exhibit an increase in the number of cells positive for markers of cell death
• survival of mouse embryonic fibroblasts followed exposure to gamma radiation is decrease compared to in similarly treated wild-type cells
• survival of mouse embryonic fibroblasts followed exposure to UV radiation is decrease compared to in similarly treated wild-type cells

embryo
• most embryos at E10.5 to E12.5
• at E11.25, some mice lack hindlimb buds

growth/size/body
• most embryos at E10.5 to E12.5
• in some surviving mice at E11.25

homeostasis/metabolism
• mouse embryonic fibroblasts exhibit reduced microhomologous DNA damage repair ability compared to in wild-type cells
• mouse embryonic fibroblasts exhibit defects in repair of UV irradiation damage
• however, less precise ligation and end joining is normal
• 37% of mouse embryo fibroblasts exhibit lagging chromosomes and unequal segregation during replication

limbs/digits/tail
• at E11.25, some mice lack hindlimb buds




Genotype
MGI:3812163
ht2
Allelic
Composition
Sirt1tm1.1Cxd/Sirt1+
Genetic
Background
either: (involves: 129S6/SvEvTac * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * C57BL/6 * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt1tm1.1Cxd mutation (0 available); any Sirt1 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in some mice




Genotype
MGI:3812167
cx3
Allelic
Composition
Sirt1tm1.1Cxd/Sirt1tm1.1Cxd
Trp53tm1Brd/Trp53tm1Brd
Genetic
Background
either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt1tm1.1Cxd mutation (0 available); any Sirt1 mutation (51 available)
Trp53tm1Brd mutation (7 available); any Trp53 mutation (152 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only one mouse survives birth
• no mice are alive at weaning
• fewer than expected mice are alive at E15.5




Genotype
MGI:3812169
cx4
Allelic
Composition
Sirt1tm1.1Cxd/Sirt1tm1.1Cxd
Trp53tm1Brd/Trp53+
Genetic
Background
either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt1tm1.1Cxd mutation (0 available); any Sirt1 mutation (51 available)
Trp53tm1Brd mutation (7 available); any Trp53 mutation (152 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 5 mice are alive at weaning
• fewer than expected mice survive to birth
• fewer than expected mice are alive at E15.5




Genotype
MGI:3812172
cx5
Allelic
Composition
Sirt1tm1.1Cxd/Sirt1+
Trp53tm1Brd/Trp53+
Genetic
Background
either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt1tm1.1Cxd mutation (0 available); any Sirt1 mutation (51 available)
Trp53tm1Brd mutation (7 available); any Trp53 mutation (152 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• tumors exhibit extensive aneuploidy and chromosomal aberrations, notably translocations, chromosome breaks, deletions and dicentric chromosomes
• mice begin to develop tumors at 5 months of age with tumor incidence reaching 76% by 20 months of age compared to only 2 of 21 Sirt1tm1.1Cxd heterozygotes and 3 of 23 Trp53tm1Brd heterozygotes
• however, treatment of mice with resveratrol decreases the incidence of tumors and delays onset
• 35% of tumors are lymphomas
• 16% of tumors are carcinomas
• 46% of tumors are sarcomas
• 22% of tumors are teratomas





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory