Mouse Genome Informatics
hm1
    Itm2btm1.1Ldad/Itm2btm1.1Ldad
involves: 129
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• mice spend the same time exploring a novel and familiar object introduced 24 hours prior unlike wild-type mice
• mice exhibit impaired spatial working memory compared with wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Cerebral Amyloid Angiopathy, Itm2b-Related, 1 176500 J:166696


Mouse Genome Informatics
hm2
    Itm2btm1.1Ldad/Itm2btm1.1Ldad
involves: 129 * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• at 11 months of age levels of soluble APP-alpha and APP-beta are increased in the brain
• however, no obvious change in overall APP levels is detected


Mouse Genome Informatics
ht3
    Itm2btm1.1Ldad/Itm2b+
B6.129-Itm2btm1.1Ldad
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• mice spend equal time exploring novel and old objects unlike wild-type mice
• mice exhibit impaired spatial working memory in a radial-arm water maze compared with wild-type mice

nervous system

Mouse Models of Human Disease
OMIM IDRef(s)
Cerebral Amyloid Angiopathy, Itm2b-Related, 2 117300 J:167154


Mouse Genome Informatics
cx4
    Itm2btm1.1Ldad/Itm2b+
Tg(APPswe,PSEN1dE9)85Dbo/0

involves: 129 * C3H * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• obvious increase in soluble APP-alpha in brain homogenates
• significant increase in both Abeta40 and Abeta42 compared to mice wild-type for Itm2b