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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Itm2btm1.1Ldad
targeted mutation 1.1, Luciano D'Adamio
MGI:3810987
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Itm2btm1.1Ldad/Itm2btm1.1Ldad involves: 129 MGI:4867887
hm2
Itm2btm1.1Ldad/Itm2btm1.1Ldad involves: 129 * C57BL/6J MGI:3810991
ht3
Itm2btm1.1Ldad/Itm2b+ B6.129-Itm2btm1.1Ldad MGI:4936846
cx4
Itm2btm1.1Ldad/Itm2b+
Tg(APPswe,PSEN1dE9)85Dbo/0
involves: 129 * C3H * C57BL/6 MGI:3810993


Genotype
MGI:4867887
hm1
Allelic
Composition
Itm2btm1.1Ldad/Itm2btm1.1Ldad
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2btm1.1Ldad mutation (0 available); any Itm2b mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice spend the same time exploring a novel and familiar object introduced 24 hours prior unlike wild-type mice (J:166696)
• mice spend the same time exploring a novel and familiar object introduced 24 hours prior unlike wild-type mice (J:166696)
• mice exhibit impaired spatial working memory compared with wild-type mice (J:166696)
• mice exhibit impaired spatial working memory compared with wild-type mice (J:166696)

Mouse Models of Human Disease
OMIM ID Ref(s)
Cerebral Amyloid Angiopathy, Itm2b-Related, 1 176500 J:166696




Genotype
MGI:3810991
hm2
Allelic
Composition
Itm2btm1.1Ldad/Itm2btm1.1Ldad
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2btm1.1Ldad mutation (0 available); any Itm2b mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 11 months of age levels of soluble APP-alpha and APP-beta are increased in the brain (J:138796)
• however, no obvious change in overall APP levels is detected (J:138796)
• at 11 months of age levels of soluble APP-alpha and APP-beta are increased in the brain (J:138796)
• however, no obvious change in overall APP levels is detected (J:138796)




Genotype
MGI:4936846
ht3
Allelic
Composition
Itm2btm1.1Ldad/Itm2b+
Genetic
Background
B6.129-Itm2btm1.1Ldad
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2btm1.1Ldad mutation (0 available); any Itm2b mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice spend equal time exploring novel and old objects unlike wild-type mice (J:167154)
• mice spend equal time exploring novel and old objects unlike wild-type mice (J:167154)
• mice exhibit impaired spatial working memory in a radial-arm water maze compared with wild-type mice (J:167154)
• mice exhibit impaired spatial working memory in a radial-arm water maze compared with wild-type mice (J:167154)

nervous system

Mouse Models of Human Disease
OMIM ID Ref(s)
Cerebral Amyloid Angiopathy, Itm2b-Related, 2 117300 J:167154




Genotype
MGI:3810993
cx4
Allelic
Composition
Itm2btm1.1Ldad/Itm2b+
Tg(APPswe,PSEN1dE9)85Dbo/0
Genetic
Background
involves: 129 * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2btm1.1Ldad mutation (0 available); any Itm2b mutation (3 available)
Tg(APPswe,PSEN1dE9)85Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• obvious increase in soluble APP-alpha in brain homogenates (J:138796)
• significant increase in both Abeta40 and Abeta42 compared to mice wild-type for Itm2b (J:138796)
• obvious increase in soluble APP-alpha in brain homogenates (J:138796)
• significant increase in both Abeta40 and Abeta42 compared to mice wild-type for Itm2b (J:138796)





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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory