Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpsm1tm1.1Lajb mutation
(1 available);
any
Gpsm1 mutation
(42 available)
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renal/urinary system
N |
• mice exhibit normal kidney sizes and blood urea nitrogen levels and no evidence of cyst formation
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpsm1tm1.1Lajb mutation
(1 available);
any
Gpsm1 mutation
(42 available)
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growth/size/body
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• becomes apparent at 10 - 12 weeks of age
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adipose tissue
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• apparent at 10 weeks of age
• by 5.5 months of age body fat is reduced by 6% compared to controls
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behavior/neurological
homeostasis/metabolism
cardiovascular system
N |
• despite differences in mean arterial pressure, heart rate and diurnal variation in heart rate are similar to controls
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• reduction in mean arterial pressure and diurnal variations in mean arterial pressure
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• increased in sensitivity to the vasodilator sodium nitroprusside as indicted by impaired compensation following vasodilation
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nervous system
N |
• despite expression in the brain in wild-type mice, no obvious defects in brain morphology are detected at 3 weeks, 6 weeks or 6 months of age
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• enhanced gain of the spontaneous baroreceptor reflex
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muscle
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• increased in sensitivity to the vasodilator sodium nitroprusside as indicted by impaired compensation following vasodilation
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpsm1tm1.1Lajb mutation
(1 available);
any
Gpsm1 mutation
(42 available)
Pkd1tm1.1Fqi mutation
(0 available);
any
Pkd1 mutation
(153 available)
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homeostasis/metabolism
renal/urinary system
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• mice exhibit an increase in cyst progression compared to single Pkd1 homozygotes
• proliferating cell nuclear antigen-positive renal cystic epithelial cells are higher than in single Pkd1 homozygous kidneys
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• kidney-to-body weight ratio is higher than in single Pkd1 homozygotes or wild-type mice at P11-12
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• renal function is reduced in double mutants more than in single Pkd1 homozygotes as indicating by a larger increase in blood urea nitrogen and plasma creatinine levels
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growth/size/body
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• mice exhibit an increase in cyst progression compared to single Pkd1 homozygotes
• proliferating cell nuclear antigen-positive renal cystic epithelial cells are higher than in single Pkd1 homozygous kidneys
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• kidney-to-body weight ratio is higher than in single Pkd1 homozygotes or wild-type mice at P11-12
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpsm1tm1.1Lajb mutation
(1 available);
any
Gpsm1 mutation
(42 available)
Pkd1tm1.1Fqi mutation
(0 available);
any
Pkd1 mutation
(153 available)
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homeostasis/metabolism
renal/urinary system
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• kidney-to-body weight ratio is higher at P11-12 than in wild-type mice but similar to that in single Pkd1 homozygotes
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growth/size/body
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• kidney-to-body weight ratio is higher at P11-12 than in wild-type mice but similar to that in single Pkd1 homozygotes
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