Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy1tm1.1Ito mutation
(1 available);
any
Adcy1 mutation
(70 available)
|
|
|
nervous system
|
• ventrobasal thalamic barreloids are not as distinct as in wild-type mice
|
|
• pre- and post-synaptic signaling of thalamocortical neurons is impaired
|
nervous system
N |
• despite abnormal barrel cortex morphology, lesion-induced plasticity of the thalamocortical axonal pattern and synaptic release efficacy are normal
|
|
• while gross barrel patterning is normal, barrel wall formation is disrupted
• dendritic orientation of layer IV neurons in the barrel cortex is impaired and dendritic span is increased compared to in wild-type micedendritic orientation of layer IV neurons in the barrel cortex is impaired and dendritic span is increased compared to in wild-type mice
|
|
• during thalamocorical synapse development
|
|
• AMPA receptor mini-excitatory postsynaptic currents of thalamocortical synapses are smaller than in wild-type mice
|
nervous system
N |
• despite abnormal barrel cortex morphology, lesion-induced plasticity of the thalamocortical axonal pattern and synaptic release efficacy are normal
|
|
• while gross barrel patterning is normal, barrel wall formation is disrupted
• dendritic orientation of layer IV neurons in the barrel cortex is impaired and dendritic span is increased compared to in wild-type micedendritic orientation of layer IV neurons in the barrel cortex is impaired and dendritic span is increased compared to in wild-type mice
|
|
• during thalamocorical synapse development
|
|
• AMPA receptor mini-excitatory postsynaptic currents of thalamocortical synapses are smaller than in wild-type mice
|