Phenotypes associated with this allele

• Allele Symbol: Sost^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:3797839
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sost^tm1(KOMP)Vlcg/Sost^tm1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:4882107
hm2	Sost^tm1(KOMP)Vlcg/Sost^tm1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:5451076
hm3	Sost^tm1(KOMP)Vlcg/Sost^tm1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:5546243
cn4	Sost^tm1(KOMP)Vlcg/Sost^tm2.1Vlcg Tg(Nanog-cre)#Vlcg/0	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5546242

Genotype
MGI:4882107

hm1

• Allelic Composition: Sost^{tm1(KOMP)Vlcg}/Sost^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac
• Cell Lines: 10069B-C10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Higher bone mass in Rr20^tm1.1Vlcg/Rr20^tm1.1Vlcg and Sost^{tm1(KOMP)Vlcg}/Sost^{tm1(KOMP)Vlcg} mice

skeleton

skeleton phenotype ( J:188586 )

N • mice exhibit normal osteoclast activity

increased compact bone area ( J:188586 )

abnormal osteoblast morphology ( J:188586 )

• 3-fold increase in bone formation at the distal femur

• increased bone formation at the endocortical surface of the femur midshaft

abnormal trabecular bone morphology ( J:188586 )

• lower trabecular separation, increased osteoblast surface and reduced structure model index at 6 months

increased trabecular bone volume ( J:188586 )

• at 6 months

increased bone trabecula number ( J:188586 )

• at 6 months

increased trabecular bone connectivity density ( J:188586 )

• at 6 months

increased bone mass ( J:188586 )

• 3-fold

abnormal bone ossification ( J:188586 )

• 2-fold increase in bone formation at the distal femur

abnormal bone mineralization ( J:188586 )

• increased mineral apposition rate

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
SOST-related sclerosing bone dysplasia		DOID:0080036	OMIM:239100	J:188586

Genotype
MGI:5451076

hm2

• Allelic Composition: Sost^{tm1(KOMP)Vlcg}/Sost^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac
• Cell Lines: 10069A-G10

skeleton

decreased osteocyte apoptosis ( J:167585 )

• osteocyte apoptosis is reduced compared to in wild-type mice

increased bone mineral density of lumbar vertebrae ( J:167585 )

• increased bone mineral density of lumbar vertebrae at 4 and 6 months of age

increased bone mineral density of femur ( J:167585 )

• increased bone mineral density of femur at 4 and 6 months of age

abnormal compact bone morphology ( J:167585 )

• tibial cortical bone area, bone thickness, and polar moment of inertia are increased compared to in wild-type mice

increased compact bone area ( J:167585 )

increased compact bone thickness ( J:167585 )

abnormal trabecular bone morphology ( J:167585 )

• tibial trabecular bone fraction, thickness, and bone density are increased compared to in wild-type mice

increased trabecular bone thickness ( J:167585 )

increased bone mass ( J:167585 )

• in the tibia

cellular

decreased osteocyte apoptosis ( J:167585 )

• osteocyte apoptosis is reduced compared to in wild-type mice

Genotype
MGI:5546243

hm3

• Allelic Composition: Sost^{tm1(KOMP)Vlcg}/Sost^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac

skeleton

increased bone mineral density ( J:200671 )

increased bone volume ( J:200671 )

increased compact bone thickness ( J:200671 )

Genotype
MGI:5546242

cn4

• Allelic Composition: Sost^{tm1(KOMP)Vlcg}/Sost^tm2.1Vlcg; Tg(Nanog-cre)#Vlcg/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

skeleton

increased bone mineral density ( J:200671 )

increased bone volume ( J:200671 )

increased compact bone thickness ( J:200671 )