Phenotypes associated with this allele

• Allele Symbol: Neu4^tm1Avps
• Allele Name: targeted mutation 1, Alexey V Pschezhetsky
• Allele ID: MGI:3793789
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Neu4^tm1Avps/Neu4^tm1Avps	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3795678

Genotype
MGI:3795678

hm1

• Allelic Composition: Neu4^tm1Avps/Neu4^tm1Avps
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:135246 )

N • mice have normal lifespan

homeostasis/metabolism

abnormal lipid level ( J:135246 )

• mice exhibit a 10-fold increase in phosphatidylcholine and ceramide levels in the lungs compared to in wild-type mice

• ceramide and fatty acid levels in the spleen are increased compared to in wild-type mice

increased cholesterol level ( J:135246 )

• mice exhibit a 10-fold increase in cholesterol levels in the lungs compared to in wild-type mice

• cholesterol levels in the spleen are increased compared to in wild-type mice

increased unsaturated fatty acids level ( J:135246 )

• mice exhibit a 2-fold increase in polyunsaturated fatty acid levels in the lungs compared to in wild-type mice

cellular

abnormal lysosome physiology ( J:135246 )

• mice exhibit vacuolization of the lungs and spleen indicate lysosomal storage disorder

reproductive system

reproductive system phenotype ( J:135246 )

N • mice are fertile

behavior/neurological

behavior/neurological phenotype ( J:135246 )

N • mice exhibit normal behavior in open field, water maze and rotarod tests at 2 and 10 months of age

growth/size/body

growth/size/body region phenotype ( J:135246 )

N • mice grow normally