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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6*)1Lnwd
transgene insertion 1, Leslie Leinwand
MGI:3793766
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Myh6*)1Lnwd/Tg(Myh6*)1Lnwd involves: C57BL/6 * FVB/N MGI:5908349
tg2
Tg(Myh6*)1Lnwd/0 involves: C57BL/6 * FVB/N MGI:5908275


Genotype
MGI:5908349
tg1
Allelic
Composition
Tg(Myh6*)1Lnwd/Tg(Myh6*)1Lnwd
Genetic
Background
involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle

cardiovascular system
• hearts exhibit more severe cellular hypertrophy, myocyte disorganization and small vessel pathology than hemizygous mice
• hearts exhibit small vessel pathology
• mitral valves are thickened with fibrous plaques, and frequent thrombus formation
• mean heart weight-to-tibia length ratio is increased in 10 month old female mice
• systolic anterior wall thickness is greater in 6 month old females
• however, no hypertrophy of the posterior wall in systole or diastole is seen
• echocardiograms of 6 month old females indicated greater anterior wall hypertrophy than in hemizygous mice
• however, systolic function, as assessed by left ventricular shortening fraction, does not differ from wild-type mice

homeostasis/metabolism
• frequent thrombus formation in mitral valves

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypertrophic cardiomyopathy 14 DOID:0110320 OMIM:613251
J:55938




Genotype
MGI:5908275
tg2
Allelic
Composition
Tg(Myh6*)1Lnwd/0
Genetic
Background
involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• hearts exhibit cellular hypertrophy, myocyte disorganization and small vessel pathology
• hearts exhibit myocyte disorganization
• heart mass is 40% greater than in wild-type mice at 10 months, but not 2 months of age, indicating development of cardiac hypertrophy
• hypertrophy is restricted to the left ventricle and is not seen in the right ventricle or atria
• hearts exhibit small vessel pathology, with hypertrophied vessels in 10 week old mice
• mitral valves are thickened with fibrous plaques, and frequent thrombus formation
• 1 of 6 mice show tricuspid valve pathology, involving the septal leaflet with a fibrous plaque on the right ventricular septal wall
• systolic anterior wall thickness is greater in 6 month old females
• however, no hypertrophy of the posterior wall in systole or diastole is seen
• ventricular myocytes exhibit reduced rates of relaxation after flash photolysis of diazo 2
• echocardiograms of 6 month old females indicate asymmetric anterior wall hypertrophy
• however, systolic function, as assessed by left ventricular shortening fraction, does not differ from wild-type mice
• ventricular myocytes exhibit decreased calcium sensitivity of tension

homeostasis/metabolism
• frequent thrombus formation in mitral valves

muscle
• hearts exhibit myocyte disorganization
• heart mass is 40% greater than in wild-type mice at 10 months, but not 2 months of age, indicating development of cardiac hypertrophy
• hypertrophy is restricted to the left ventricle and is not seen in the right ventricle or atria
• ventricular myocytes exhibit reduced rates of relaxation after flash photolysis of diazo 2

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypertrophic cardiomyopathy 14 DOID:0110320 OMIM:613251
J:55938





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory