About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6*)131Lnwd
transgene insertion 131, Leslie Leinwand
MGI:3793714
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Myh6*)131Lnwd/0 involves: C57BL/6 * CBA MGI:5286085


Genotype
MGI:5286085
tg1
Allelic
Composition
Tg(Myh6*)131Lnwd/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• left ventricular hypertrophy (10% increase) is observed by 14-15 weeks of age

cardiovascular system
• mutants exhibit abnormal cardiac histopathology, but do not exhibit cardiac hypertrophy at 12 weeks of age, indicating a less severe phenotype than Tg(Myh6*)140Lnwd/0 mice
• mutants exhibit hypertrophic cardiomyopathy including focal myocyte hypertrophy and myocellular disarray with increased matrix accumulation
• left ventricular hypertrophy (10% increase) is observed by 14-15 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypertrophic cardiomyopathy 14 DOID:0110320 OMIM:613251
J:31537





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2019
MGI 6.14
The Jackson Laboratory