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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nr1i2tm3Arte
targeted mutation 3, TaconicArtemis
MGI:3790846
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nr1i2tm3Arte/Nr1i2tm3Arte involves: C57BL/6 MGI:3815123
cx2
 		Nr1i2tm3Arte/Nr1i2tm3Arte
Nr1i3tm1.1Arte/Nr1i3tm1.1Arte 		involves: C57BL/6NTac MGI:3815126


Genotype
MGI:3815123
hm1
Allelic
Composition		 Nr1i2tm3Arte/Nr1i2tm3Arte
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1i2tm3Arte mutation (3 available); any Nr1i2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:140975 )
N
• mice exhibit normal survival

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:140975 )
• mice do not exhibit RIF or dexamethasome induced Cyp3a11 expression
• however, mice exhibit normal induction of Cyp2b10 expression following treatment with dexamethasone

liver/biliary system
liver/biliary system phenotype ( J:140975 )
N
• mice exhibit normal liver histology

reproductive system
reproductive system phenotype ( J:140975 )
N
• mice exhibit normal fertility




Genotype
MGI:3815126
cx2
Allelic
Composition		 Nr1i2tm3Arte/Nr1i2tm3Arte
Nr1i3tm1.1Arte/Nr1i3tm1.1Arte
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1i2tm3Arte mutation (3 available); any Nr1i2 mutation (33 available)
Nr1i3tm1.1Arte mutation (4 available); any Nr1i3 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:140975 )
• mice fail to exhibit phenobarbital induced Cyp3a11 or Cyp2b10 expression




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory