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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Thy1-SOD1*G93A)T1Hgrd
transgene insertion T1, Casper Hoogenraad
MGI:3785266
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Thy1-SOD1*G93A)T1Hgrd/0
Tg(Thy1-SOD1*G93A)T3Hgrd/0
involves: C57BL/6 * CBA * FVB MGI:3785389
tg2
Tg(Thy1-SOD1*G93A)T1Hgrd/0 involves: C57BL/6 * CBA * FVB MGI:3785388


Genotype
MGI:3785389
cx1
Allelic
Composition
Tg(Thy1-SOD1*G93A)T1Hgrd/0
Tg(Thy1-SOD1*G93A)T3Hgrd/0
Genetic
Background
involves: C57BL/6 * CBA * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-SOD1*G93A)T1Hgrd mutation (0 available)
Tg(Thy1-SOD1*G93A)T3Hgrd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• at end-stage, most mice display severe weight loss (>30%) (J:134095)
• at end-stage, most mice display severe weight loss (>30%) (J:134095)

behavior/neurological
• at end-stage, severe locomotor deficits are exhibited (J:134095)
• at end-stage, severe locomotor deficits are exhibited (J:134095)
• at end-stage, loss of ability to hang in hanging wire test (J:134095)
• at end-stage, loss of ability to hang in hanging wire test (J:134095)
• loss of grip strength at end-stage of disease (J:134095)
• loss of grip strength at end-stage of disease (J:134095)

nervous system
• accumulation of argyrophilic neuronal debris is seen throughout medullary, pontine, and mesencephalic reticular formation up to zona incerta (J:134095)
• accumulation of argyrophilic neuronal debris is seen throughout medullary, pontine, and mesencephalic reticular formation up to zona incerta (J:134095)
• signs of reactive gliosis are seen at disease end-stage (J:134095)
• signs of reactive gliosis are seen at disease end-stage (J:134095)
• animals not displaying motor abnormalities show ubiquinated neurites in spinal cord (J:134095)
• animals not displaying motor abnormalities show ubiquinated neurites in spinal cord (J:134095)
• in mice at end-stage, denervation is observed at neuromuscular synapses (J:134095)
• in mice at end-stage, denervation is observed at neuromuscular synapses (J:134095)
• appears restricted to brainstem and spinal cord (J:134095)
• appears restricted to brainstem and spinal cord (J:134095)
• accumulation of argyrophilic neuronal debris is seen in spinal cord of mice at end-stage of disease; similar amounts are seen between left and right, and lumbar and cervical segments (J:134095)
• accumulation of argyrophilic neuronal debris is seen in spinal cord of mice at end-stage of disease; similar amounts are seen between left and right, and lumbar and cervical segments (J:134095)
• loss of motor neurons is detected at disease end-stage (J:134095)
• loss of motor neurons is detected at disease end-stage (J:134095)

muscle
• exhibited by most mice (67%) before 2 years of age; onset is observed at 539 days to more than 730 days with end stage reached at 591 to greater than 730 days (J:134095)
• exhibited by most mice (67%) before 2 years of age; onset is observed at 539 days to more than 730 days with end stage reached at 591 to greater than 730 days (J:134095)

cellular
N
• mice do not develop mitochondrial swelling and vacuolization like G1 or G1del mutants (J:134095)
• mice do not develop mitochondrial swelling and vacuolization like G1 or G1del mutants (J:134095)

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:134095




Genotype
MGI:3785388
tg2
Allelic
Composition
Tg(Thy1-SOD1*G93A)T1Hgrd/0
Genetic
Background
involves: C57BL/6 * CBA * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice show no clinical or pathological signs of motor abnormalities up to 2 years of age (J:134095)
• mice show no clinical or pathological signs of motor abnormalities up to 2 years of age (J:134095)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory