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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slco1b2tm1Cdk
targeted mutation 1, Curtis D Klaassen
MGI:3785252
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slco1b2tm1Cdk/Slco1b2tm1Cdk B6.129S1-Slco1b2tm1Cdk MGI:3785254
hm2
Slco1b2tm1Cdk/Slco1b2tm1Cdk involves: 129S1/Sv * C57BL/6 MGI:3785253


Genotype
MGI:3785254
hm1
Allelic
Composition
Slco1b2tm1Cdk/Slco1b2tm1Cdk
Genetic
Background
B6.129S1-Slco1b2tm1Cdk
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all 6 null mice survive after injection with 120 ug/kg microcystin-LR in contrast to wild-type mice where 3 of 6 mice died with 20 h of the injection (J:133919)
• all 6 null mice survive after injection with 120 ug/kg microcystin-LR in contrast to wild-type mice where 3 of 6 mice died with 20 h of the injection (J:133919)

homeostasis/metabolism
• increased about 2.5-fold in females, mostly as a result of an increase in conjugated bilirubin (J:133919)
• increased about 2.5-fold in females, mostly as a result of an increase in conjugated bilirubin (J:133919)
• increased by about 30% in null males compared to wild-type males (J:133919)
• increased by about 30% in null males compared to wild-type males (J:133919)
• slight but statistically significant increase in females (J:133919)
• slight but statistically significant increase in females (J:133919)
• slight but statistically significant increase in females (J:133919)
• slight but statistically significant increase in females (J:133919)
• slight but statistically significant decrease in females (J:133919)
• slight but statistically significant decrease in females (J:133919)
• slight increase in both genders (J:133919)
• slight increase in both genders (J:133919)
• slight increase in both genders (J:133919)
• slight increase in both genders (J:133919)
• slight but statistically significant increase in females (J:133919)
• slight but statistically significant increase in females (J:133919)
• all 6 null mice survive after injection with 120 ug/kg microcystin-LR in contrast to wild-type mice where 3 of 6 mice died with 20 h of the injection (J:133919)
• all 6 null mice survive after injection with 120 ug/kg microcystin-LR in contrast to wild-type mice where 3 of 6 mice died with 20 h of the injection (J:133919)
• mice do not display signs of liver injury after injection with 120 ug/kg microcystin-LR unlike wild-type mice (J:133919)
• mice do not display signs of liver injury after injection with 120 ug/kg microcystin-LR unlike wild-type mice (J:133919)

liver/biliary system
• mice do not display signs of liver injury after injection with 120 ug/kg microcystin-LR unlike wild-type mice (J:133919)
• mice do not display signs of liver injury after injection with 120 ug/kg microcystin-LR unlike wild-type mice (J:133919)




Genotype
MGI:3785253
hm2
Allelic
Composition
Slco1b2tm1Cdk/Slco1b2tm1Cdk
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• lack hepatic uptake of phalloidin and are completely protected from phalloidin-induced hepatotoxicity (2.5 mg/kg) (J:133919)
• lack hepatic uptake of phalloidin and are completely protected from phalloidin-induced hepatotoxicity (2.5 mg/kg) (J:133919)

homeostasis/metabolism
• lack hepatic uptake of phalloidin (J:133919)
• lack hepatic uptake of phalloidin (J:133919)
• completely protected from phalloidin-induced hepatotoxicity (2.5 mg/kg) (J:133919)
• however, sensitivity to alpha-amanitin-induced hepatotoxicity is similar to controls (J:133919)
• completely protected from phalloidin-induced hepatotoxicity (2.5 mg/kg) (J:133919)
• however, sensitivity to alpha-amanitin-induced hepatotoxicity is similar to controls (J:133919)





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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory