Mouse Genome Informatics
hm1
    Slco1b2tm1Cdk/Slco1b2tm1Cdk
B6.129S1-Slco1b2tm1Cdk
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• all 6 null mice survive after injection with 120 ug/kg microcystin-LR in contrast to wild-type mice where 3 of 6 mice died with 20 h of the injection

homeostasis/metabolism
• increased about 2.5-fold in females, mostly as a result of an increase in conjugated bilirubin
• increased by about 30% in null males compared to wild-type males
• slight but statistically significant increase in females
• slight but statistically significant increase in females
• slight but statistically significant decrease in females
• slight increase in both genders
• slight increase in both genders
• slight but statistically significant increase in females
• all 6 null mice survive after injection with 120 ug/kg microcystin-LR in contrast to wild-type mice where 3 of 6 mice died with 20 h of the injection
• mice do not display signs of liver injury after injection with 120 ug/kg microcystin-LR unlike wild-type mice

liver/biliary system
• mice do not display signs of liver injury after injection with 120 ug/kg microcystin-LR unlike wild-type mice


Mouse Genome Informatics
hm2
    Slco1b2tm1Cdk/Slco1b2tm1Cdk
involves: 129S1/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
liver/biliary system
• lack hepatic uptake of phalloidin and are completely protected from phalloidin-induced hepatotoxicity (2.5 mg/kg)

homeostasis/metabolism
• lack hepatic uptake of phalloidin
• completely protected from phalloidin-induced hepatotoxicity (2.5 mg/kg)
• however, sensitivity to alpha-amanitin-induced hepatotoxicity is similar to controls