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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slco1b2tm1Cdk
targeted mutation 1, Curtis D Klaassen
MGI:3785252
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slco1b2tm1Cdk/Slco1b2tm1Cdk B6.129S1-Slco1b2tm1Cdk MGI:3785254
hm2
Slco1b2tm1Cdk/Slco1b2tm1Cdk involves: 129S1/Sv * C57BL/6 MGI:3785253


Genotype
MGI:3785254
hm1
Allelic
Composition
Slco1b2tm1Cdk/Slco1b2tm1Cdk
Genetic
Background
B6.129S1-Slco1b2tm1Cdk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slco1b2tm1Cdk mutation (0 available); any Slco1b2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all 6 null mice survive after injection with 120 ug/kg microcystin-LR in contrast to wild-type mice where 3 of 6 mice died with 20 h of the injection

homeostasis/metabolism
• increased about 2.5-fold in females, mostly as a result of an increase in conjugated bilirubin
• increased by about 30% in null males compared to wild-type males
• slight but statistically significant increase in females
• slight but statistically significant increase in females
• slight but statistically significant decrease in females
• slight increase in both genders
• slight increase in both genders
• slight but statistically significant increase in females
• all 6 null mice survive after injection with 120 ug/kg microcystin-LR in contrast to wild-type mice where 3 of 6 mice died with 20 h of the injection
• mice do not display signs of liver injury after injection with 120 ug/kg microcystin-LR unlike wild-type mice

liver/biliary system
• mice do not display signs of liver injury after injection with 120 ug/kg microcystin-LR unlike wild-type mice




Genotype
MGI:3785253
hm2
Allelic
Composition
Slco1b2tm1Cdk/Slco1b2tm1Cdk
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slco1b2tm1Cdk mutation (0 available); any Slco1b2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• lack hepatic uptake of phalloidin and are completely protected from phalloidin-induced hepatotoxicity (2.5 mg/kg)

homeostasis/metabolism
• lack hepatic uptake of phalloidin
• completely protected from phalloidin-induced hepatotoxicity (2.5 mg/kg)
• however, sensitivity to alpha-amanitin-induced hepatotoxicity is similar to controls





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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory