Phenotypes associated with this allele

• Allele Symbol: Erc2^tm1.1Sud
• Allele Name: targeted mutation 1.1, Thomas C Sudhof
• Allele ID: MGI:3783990
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Erc2^tm1.1Sud/Erc2^tm1.1Sud	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:4940523
hm2	Erc2^tm1.1Sud/Erc2^tm1.1Sud	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3784013

Genotype
MGI:4940523

hm1

• Allelic Composition: Erc2^tm1.1Sud/Erc2^tm1.1Sud
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal synapse morphology ( J:155764 )

• mice exhibit a small reduction in vesicle numbers per bouton in symmetric and asymmetric synapses compared with wild-type mice

abnormal synaptic vesicle number ( J:155764 )

• mice exhibit a small reduction in vesicle numbers per bouton in symmetric and asymmetric synapses compared with wild-type mice

• mice exhibit an increase number of calcium-responsive vesicles compared with wild-type mice

• mice exhibit an increase in readily-releasable pool of inhibitory synapses compared with wild-type mice

abnormal CNS synaptic transmission ( J:155764 )

• mice exhibit a decrease in excitatory postsynaptic potential-spike coupling compared with wild-type mice

abnormal inhibitory postsynaptic currents ( J:155764 )

• mice exhibit a 2-fold increase in the amplitude of evoked inhibitory postsynaptic currents compared with wild-type mice

• mice exhibit an increase in inhibitory neurotransmitter release due to increased number of calcium-responsive vesicles compared with wild-type mice

abnormal synaptic neurotransmitter level ( J:155764 )

• mice exhibit an increase in inhibitory neurotransmitter release due to increased number of calcium-responsive vesicles compared with wild-type mice

behavior/neurological

increased exploration in new environment ( J:155764 )

Genotype
MGI:3784013

hm2

• Allelic Composition: Erc2^tm1.1Sud/Erc2^tm1.1Sud
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

nervous system

abnormal CNS synaptic transmission ( J:133656 )

• evoked IPSCs are moderately increased compared to wild-type

abnormal inhibitory postsynaptic currents ( J:133656 )

• evoked IPSCs are moderately increased compared to wild-type

abnormal synaptic neurotransmitter level ( J:133656 )

• readily releasable pool is moderately increased compared to wild-type