Phenotypes associated with this allele

• Allele Symbol: Rcan1^tm1Emar
• Allele Name: targeted mutation 1, Eulalia Marti
• Allele ID: MGI:3783735
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rcan1^tm1Emar/Rcan1^tm1Emar	involves: 129P2/OlaHsd * C57BL/6	MGI:3809582

Genotype
MGI:3809582

hm1

• Allelic Composition: Rcan1^tm1Emar/Rcan1^tm1Emar
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

oxidative stress ( J:132745 )

• cultured cerebellar granule neurons are more resistant to cell death induced by oxidative stress

endocrine/exocrine glands

abnormal adrenal gland secretion ( J:132495 )

• reduced exocytosis in chromaffin cells when stimulated with 70mM potassium for 1 minute

• initial rates of exocytosis normal for 5-10 seconds but declines rapidly thereafter

• increased amounts of catecholamine released for each fusion event involving vesicles and the cell membrane

• foot signals resulting from fusion pore formation lasted longer and resulted in increased neurotransmitter release