Phenotypes associated with this allele

• Allele Symbol: Ace^tm7Keb
• Allele Name: targeted mutation 7, Kenneth E Bernstein
• Allele ID: MGI:3783350
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ace^tm7Keb/Ace^tm7Keb	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3783351

Genotype
MGI:3783351

hm1

• Allelic Composition: Ace^tm7Keb/Ace^tm7Keb
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:92397 )

• at 66 days after birth, only 64% of mutant mice were alive as compared to 100% of wild-type and heterozygous mice

• the survival rate at 300 days was only 23% for mutant mice as compared to 100% of wild-type

premature death ( J:92397 )

• a significant incidence of sudden death after 3 weeks of age

cardiovascular system

increased heart atrium size ( J:92397 )

• in all homozygous mutant mice older than 3 weeks

• ventricular size or the degree of ventricular fibrosis was not affected

• ventricular function was essentially normal

dilated heart ( J:92397 )

• consistently found at necropsy following sudden death

• accompanied by a remarkable bilateral enlargement of the atria

atrial fibrillation ( J:92397 )

decreased systemic arterial systolic blood pressure ( J:92397 )

• systolic blood pressure was slightly lower compared to control groups

• no renal function difference were found

• the hematocrit was equivalent to the controls