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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gngt1tm1Dgen
targeted mutation 1, Deltagen
MGI:3783323
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gngt1tm1Dgen/Gngt1tm1Dgen B6.129P2-Gngt1tm1Dgen MGI:3783806
cx2
Gnat1tm1Clma/Gnat1tm1Clma
Gngt1tm1Dgen/Gngt1tm1Dgen
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 MGI:3783807
cx3
Gngt1tm1Dgen/Gngt1tm1Dgen
Pdctm1Vya/Pdctm1Vya
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 MGI:3783809


Genotype
MGI:3783806
hm1
Allelic
Composition
Gngt1tm1Dgen/Gngt1tm1Dgen
Genetic
Background
B6.129P2-Gngt1tm1Dgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gngt1tm1Dgen mutation (0 available); any Gngt1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• length is reduced by about 1/3 compared to controls at 1 month of age
• outer segments become progressively shorter with age
• progressive degeneration beginning at 1 month of age with loss of most rods by 6 months
• raising mice in complete darkness does not affect the rate of degeneration
• by 6 months of age most rods are lost with only about 3 - 4 nuclei per row compared to 10 - 11 in wild-type mice
• a-wave amplitude is 3-fold smaller than in wild-type mice but 5-fold larger than in Gnat1tm1Clma homozygous mice
• while maximal b-wave amplitude is similar to wild-type mice the half-saturating tight intensity for b-wave is about 2300-fold higher
• the flash strength needed to half-maximally activate individual rods is about 70-fold brighter than that for wild-type rods
• the amplification constant is about 24-fold smaller than that of wild-type mice

nervous system
• length is reduced by about 1/3 compared to controls at 1 month of age
• outer segments become progressively shorter with age
• progressive degeneration beginning at 1 month of age with loss of most rods by 6 months
• raising mice in complete darkness does not affect the rate of degeneration
• by 6 months of age most rods are lost with only about 3 - 4 nuclei per row compared to 10 - 11 in wild-type mice




Genotype
MGI:3783807
cx2
Allelic
Composition
Gnat1tm1Clma/Gnat1tm1Clma
Gngt1tm1Dgen/Gngt1tm1Dgen
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnat1tm1Clma mutation (1 available); any Gnat1 mutation (14 available)
Gngt1tm1Dgen mutation (0 available); any Gngt1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• degeneration proceeds at a rate similar to that in Gngt1 single homozygotes

nervous system
• degeneration proceeds at a rate similar to that in Gngt1 single homozygotes




Genotype
MGI:3783809
cx3
Allelic
Composition
Gngt1tm1Dgen/Gngt1tm1Dgen
Pdctm1Vya/Pdctm1Vya
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gngt1tm1Dgen mutation (0 available); any Gngt1 mutation (8 available)
Pdctm1Vya mutation (1 available); any Pdc mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• degeneration proceeds at a rate similar to that in Gngt1 single homozygotes

vision/eye
• degeneration proceeds at a rate similar to that in Gngt1 single homozygotes





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory