Mouse Genome Informatics
cx1
    Tg(Prnp-ITM2B*)7Jckr/0
Tg(Thy1-MAPT*P301S)2541Godt/0

B6.Cg-Tg(Prnp-ITM2B*)7Jckr Tg(Thy1-MAPT*P301S)2541Godt
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• at 12 months, mice exhibit a greater than 50-fold increase in Gallyas+ neurofibrillary pathology compared with Tg(Thy1-MAPT*P301S)2541Godt mice
• at 12 months, mice exhibit an 18-fold increase in neocortex Tau inclusions compared with Tg(Thy1-MAPT*P301S)2541Godt mice


Mouse Genome Informatics
cx2
    Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Tg(Thy1-MAPT*P301S)2541Godt/0

B6.Cg-Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr Tg(Thy1-MAPT*P301S)2541Godt
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• at 12 months, mice exhibit a 3- to 4-fold increase in Tau lesions compared with Tg(Thy1-MAPT*P301S)2541Godt mice


Mouse Genome Informatics
tg3
    Tg(Thy1-MAPT*P301S)2541Godt/Tg(Thy1-MAPT*P301S)2541Godt
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)
EuPh (J:165965)

growth/size/body
EuPh (J:165965)

hematopoietic system
EuPh (J:165965)

homeostasis/metabolism

immune system

other phenotype
EuPh (J:165965)