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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Thy1-MAPT*P301S)2541Godt
transgene insertion 2541, Michel Goedert
MGI:3778191
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Prnp-ITM2B*)7Jckr/0
Tg(Thy1-MAPT*P301S)2541Godt/0
B6.Cg-Tg(Prnp-ITM2B*)7Jckr Tg(Thy1-MAPT*P301S)2541Godt MGI:4452491
cx2
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Tg(Thy1-MAPT*P301S)2541Godt/0
B6.Cg-Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr Tg(Thy1-MAPT*P301S)2541Godt MGI:4452492
tg3
Tg(Thy1-MAPT*P301S)2541Godt/Tg(Thy1-MAPT*P301S)2541Godt involves: C57BL/6J * CBA/Ca MGI:5450673


Genotype
MGI:4452491
cx1
Allelic
Composition
Tg(Prnp-ITM2B*)7Jckr/0
Tg(Thy1-MAPT*P301S)2541Godt/0
Genetic
Background
B6.Cg-Tg(Prnp-ITM2B*)7Jckr Tg(Thy1-MAPT*P301S)2541Godt
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 12 months, mice exhibit a greater than 50-fold increase in Gallyas+ neurofibrillary pathology compared with Tg(Thy1-MAPT*P301S)2541Godt mice
• at 12 months, mice exhibit an 18-fold increase in neocortex Tau inclusions compared with Tg(Thy1-MAPT*P301S)2541Godt mice




Genotype
MGI:4452492
cx2
Allelic
Composition
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Tg(Thy1-MAPT*P301S)2541Godt/0
Genetic
Background
B6.Cg-Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr Tg(Thy1-MAPT*P301S)2541Godt
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 12 months, mice exhibit a 3- to 4-fold increase in Tau lesions compared with Tg(Thy1-MAPT*P301S)2541Godt mice




Genotype
MGI:5450673
tg3
Allelic
Composition
Tg(Thy1-MAPT*P301S)2541Godt/Tg(Thy1-MAPT*P301S)2541Godt
Genetic
Background
involves: C57BL/6J * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice are unable to extend their hindlimbs when lifted by the tail
• mice develop tremor at 5-6 months of age
• mice develop severe paraparesis by 5-6 months of age

muscle
• atrophic, angulated muscle fibers are frequently seen in hindlimb skeletal muscle, indicative of denervation atrophy
• mice develop general muscle weakness at 5-6 months of age

nervous system
• large numbers of abnormal tau filaments are seen in the cytoplasm and processes of nerve cells from 5-6 month old mice
• majority of filaments resemble half-twisted ribbons seen in FTDP-17, while a minority resemble paired helical filaments of Alzheimers disease
• reactive astrocytosis in the motor neurons of the anterior horn of the spinal cord
• reduction in the number of motor neurons in the ventral gray matter of 6 month old mutants
• 49% reduction in the number of motor neurons in the anterior horn of the spinal cord
• neuronal cell bodies are often swollen or severely atrophic
• occasionally pyknotic neurons are surrounded by glial cells, suggesting neuronophagia

vision/eye

immune system

Mouse Models of Human Disease
OMIM ID Ref(s)
Frontotemporal Dementia; FTD 600274 J:108870





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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory