About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc17a8tm1Edw
targeted mutation 1, Robert H Edwards
MGI:3777601
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slc17a8tm1Edw/Slc17a8tm1Edw involves: 129P2/OlaHsd * C57BL/6 MGI:3777618
ht2
 		Slc17a8tm1Edw/Slc17a8+ involves: 129P2/OlaHsd * C57BL/6 MGI:3777619


Genotype
MGI:3777618
hm1
Allelic
Composition		 Slc17a8tm1Edw/Slc17a8tm1Edw
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc17a8tm1Edw mutation (1 available); any Slc17a8 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nonconvulsive seizures ( J:132704 )
• mice exhibit intermittent spontaneous cortical seizures lasting up to 2 minutes
• however, mice do not display any behavioral abnormalities
abnormal inner hair cell synaptic ribbon morphology ( J:132704 )
• 26 of 31 inner cell synapses exhibit abnormally thin, elongated ribbons
cochlear ganglion degeneration ( J:132704 )
• mice exhibit progressive neuron loss at all levels of the cochlea that is apparent by P10
abnormal brain wave pattern ( J:132704 )
• mice exhibit frequent interictal spike discharges
decreased synaptic glutamate release ( J:132704 )
• mice do not exhibit no synaptic response in the inner hair cell afferent terminals even when depolarized by elevated potassium

hearing/vestibular/ear
abnormal inner hair cell synaptic ribbon morphology ( J:132704 )
• 26 of 31 inner cell synapses exhibit abnormally thin, elongated ribbons

behavior/neurological
absent startle reflex ( J:132704 )
• mice do not startle to a loud clap
• however, motor and vestibular functions are normal
nonconvulsive seizures ( J:132704 )
• mice exhibit intermittent spontaneous cortical seizures lasting up to 2 minutes
• however, mice do not display any behavioral abnormalities




Genotype
MGI:3777619
ht2
Allelic
Composition		 Slc17a8tm1Edw/Slc17a8+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc17a8tm1Edw mutation (1 available); any Slc17a8 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain wave pattern ( J:132704 )
• mice exhibit interictal epileptiform abnormalities but no detectable electrographic seizure




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory