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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cryaatm1.1Ady
targeted mutation 1.1, Usha P Andley
MGI:3777403
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cryaatm1.1Ady/Cryaatm1.1Ady involves: 129 * C57BL/6 MGI:3784583
ht2
Cryaatm1.1Ady/Cryaa+ involves: 129 * C57BL/6 MGI:3784582


Genotype
MGI:3784583
hm1
Allelic
Composition
Cryaatm1.1Ady/Cryaatm1.1Ady
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cryaatm1.1Ady mutation (0 available); any Cryaa mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Lens opacity in Cryaatm1.1Ady/Cryaa+, and Cryaatm1.1Ady/Cryaatm1.1Ady mice and microphthalmia in Cryaatm1.1Ady/Cryaatm1.1Ady mice

vision/eye
• increased amounts of alphaA-crystallin and alphaB-crystallin in the lens-insoluble fractions
• a rapid onset of cataract that stabilized between 8 and 12 weeks
• stage 3 and 4 lens opacities were observed in 5- and 16-week-old homozygous mice
• severe in the nuclear region of the lens in newborn mice
• weight of eyes are 60-70% less than wild-type and heterozygous littermates which was mainly due to the decrease in lens weight
• severe microphthalmia
• weight of eyes are 60-70% less than wild-type and heterozygous littermates which was mainly due to the decrease in lens weight

cellular

Mouse Models of Human Disease
OMIM ID Ref(s)
Cataract 9, Multiple Types; CTRCT9 604219 J:132296




Genotype
MGI:3784582
ht2
Allelic
Composition
Cryaatm1.1Ady/Cryaa+
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cryaatm1.1Ady mutation (0 available); any Cryaa mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Lens opacity in Cryaatm1.1Ady/Cryaa+, and Cryaatm1.1Ady/Cryaatm1.1Ady mice and microphthalmia in Cryaatm1.1Ady/Cryaatm1.1Ady mice

vision/eye
• increased amounts of alphaA-crystallin and alphaB-crystallin in the lens-insoluble fractions at lesser degree than homozygous mice
• less severe lens opacities in heterozygous mice compared to homozygotes

Mouse Models of Human Disease
OMIM ID Ref(s)
Cataract 9, Multiple Types; CTRCT9 604219 J:132296





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory