Mouse Genome Informatics
hm1
    Cryaatm1.1Ady/Cryaatm1.1Ady
involves: 129 * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Lens opacity in Cryaatm1.1Ady/Cryaa+, and Cryaatm1.1Ady/Cryaatm1.1Ady mice and microphthalmia in Cryaatm1.1Ady/Cryaatm1.1Ady mice

vision/eye
• increased amounts of alphaA-crystallin and alphaB-crystallin in the lens-insoluble fractions
• a rapid onset of cataract that stabilized between 8 and 12 weeks
• stage 3 and 4 lens opacities were observed in 5- and 16-week-old homozygous mice
• severe in the nuclear region of the lens in newborn mice
• weight of eyes are 60-70% less than wild-type and heterozygous littermates which was mainly due to the decrease in lens weight
• severe microphthalmia
• weight of eyes are 60-70% less than wild-type and heterozygous littermates which was mainly due to the decrease in lens weight

cellular

Mouse Models of Human Disease
OMIM IDRef(s)
Cataract 9, Multiple Types; CTRCT9 604219 J:132296


Mouse Genome Informatics
ht2
    Cryaatm1.1Ady/Cryaa+
involves: 129 * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Lens opacity in Cryaatm1.1Ady/Cryaa+, and Cryaatm1.1Ady/Cryaatm1.1Ady mice and microphthalmia in Cryaatm1.1Ady/Cryaatm1.1Ady mice

vision/eye
• increased amounts of alphaA-crystallin and alphaB-crystallin in the lens-insoluble fractions at lesser degree than homozygous mice
• less severe lens opacities in heterozygous mice compared to homozygotes

Mouse Models of Human Disease
OMIM IDRef(s)
Cataract 9, Multiple Types; CTRCT9 604219 J:132296