About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
CrygbS11R
S11R
MGI:3777015
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
CrygbS11R/CrygbS11R A/J-CrygbS11R MGI:3777759
ht2
CrygbS11R/Crygb+ A/J-CrygbS11R MGI:3777758
cx3
CrygbS11R/CrygbS11R
Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
involves: A/J * C57BL/6J MGI:6099062


Genotype
MGI:3777759
hm1
Allelic
Composition
CrygbS11R/CrygbS11R
Genetic
Background
A/J-CrygbS11R
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
CrygbS11R mutation (1 available); any Crygb mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• at 220-350 um from lens capsule, lenses display unique ringlike structure which causes abnormal light scattering (J:132502)
• at 1 day of age lenses show a lack of F-actin and extremely low levels of cystosolic gamma-crystallin in interior fiber cells and substantial membrane-associated gamma-crystallin aggregates in the lens. Assessment at 10 days of age finds elevated total calcium in the lens. (J:165131)
• inner fiber cells of lenses show uneven toluidine blue staining with abnormally darkly stained areas at P3 (J:132502)
• at P21, peripheral fiber cells are relatively normal, similar to wild-type (J:132502)
• in some animals, disintegrated fibers appear in core of lens while lens peripheral fiber cells have normal morphology (J:132502)
• fiber cells of the lens core show enlargement of extracellular spaces, disrupted fiber-to-fiber contact, and deterioration of intracellular components (J:165131)
• mice develop dense nuclear cataracts by weaning age (P21); cataract can be visualized at P7, but not at P1
• cataracts occur with full penetrance on various backgrounds (coisogenic A/J, or mixed A/J and C57BL/6J or 129 backgrounds)
• periphery of lens remains transparent, even in older mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cataract 39 multiple types DOID:0110236 OMIM:615188
J:132502




Genotype
MGI:3777758
ht2
Allelic
Composition
CrygbS11R/Crygb+
Genetic
Background
A/J-CrygbS11R
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
CrygbS11R mutation (1 available); any Crygb mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• at 220-350 um from lens capsule, lenses display unique ringlike structure which causes abnormal light scattering
• inner fiber cells of lenses show uneven toluidine blue staining with abnormally darkly stained areas at P3
• at P21, peripheral fiber cells are relatively normal, similar to wild-type
• mice display hazy nuclear cataracts by weaning age
• periphery of lens remains transparent, even in older mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cataract 39 multiple types DOID:0110236 OMIM:615188
J:132502




Genotype
MGI:6099062
cx3
Allelic
Composition
CrygbS11R/CrygbS11R
Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic
Background
involves: A/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
CrygbS11R mutation (1 available); any Crygb mutation (12 available)
Gja8tm1(Gja3)Tww mutation (0 available); any Gja8 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• the enlarged extracellular spaces and disrupted fiber-to-fiber contacts in the fiber cells of the lens core of crystallin gamma b mutants is rescued in these double homozygotes
• while the alpha 3 connexin knockin rescues the dense nuclear cataract otherwise caused by the crystallin gamma b mutation, a very mild cortical opacity with a ring-like defect is still found in these double homozygotes and the lenses have much lower light scattering at 21 days of age compared with un-rescued crystallin gamma b mutants, but is still 6% higher than wild-type controls





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/12/2022
MGI 6.17
The Jackson Laboratory