Mouse Genome Informatics
cx1
    Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-S100a10)1Pggd/0

involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• mice exhibit decreased depression-related behavior such as immobility when suspended by their tails
• however, treatment with doxycycline restores normal depression-related behaviors
• mice exhibit decreased thigmotaxis and increased horizontal activity in an open-field test
• however, treatment with doxycycline restores normal anxiety-related behaviors