Analysis Tools
reproductive system
| N |
• unlike in mice homozygous for Esr2tm1Unc, mice do not exhibit an increase in collagen deposition and vascularization of the theca layer, mammary gland development, and prostate morphology, cell proliferation and apoptosis are normal
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• unlike in wild-type mice, corpora lutea are rare
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• mice exhibit an increase in the number of atretic follicles
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• when superovulated, mice fail to release any oocytes unlike wild-type mice
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• irregular cycling
|
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• despite normal testes and mobile spermatozoa, male mice are infertile
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endocrine/exocrine glands
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• unlike in wild-type mice, corpora lutea are rare
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• mice exhibit an increase in the number of atretic follicles
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digestive/alimentary system
| N |
• unlike in mice homozygous for Esr2tm1Unc, colon morphology is normal
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immune system
| N |
• unlike in mice homozygous for Esr2tm1Unc, lymphoid organ morphology and lymphocyte numbers are normal
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nervous system
| N |
• unlike in mice homozygous for Esr2tm1Unc, brain morphology at 16 months of age is normal
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renal/urinary system
| N |
• unlike in mice homozygous for Esr2tm1Unc, urinary bladder morphology is normal
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cardiovascular system
| N |
• unlike in mice homozygous for Esr2tm1Unc, heart morphology is normal
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respiratory system
| N |
• unlike in mice homozygous for Esr2tm1Unc, lung morphology is normal
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