Phenotypes associated with this allele

• Allele Symbol: Hcn4^tm1Rsei
• Allele Name: targeted mutation 1, Reinhart Seifert
• Allele ID: MGI:3775108
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hcn4^tm1Rsei/Hcn4^tm1Rsei	B6.Cg-Hcn4^tm1Rsei	MGI:3776790
ht2	Hcn4^tm1Rsei/Hcn4^+	B6.Cg-Hcn4^tm1Rsei	MGI:3776791

Genotype
MGI:3776790

hm1

• Allelic Composition: Hcn4^tm1Rsei/Hcn4^tm1Rsei
• Genetic Background: B6.Cg-Hcn4^tm1Rsei

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:131820 )

• homozygotes develop normally until E11 but are dead by E12

cardiovascular system

decreased cardiac muscle contractility ( J:131820 )

• isolated cardiomyocytes beat more slowly

• slower activation of currents in cardiomyocytes

• faster deactivation of currents in cardiomyocytes

decreased heart rate ( J:131820 )

• embryos display a reduced heart rate between E9.5 and E11.5

• superfusion of either isoproterenol or NKH477 fails to bring about an increase in heart rate

muscle

decreased cardiac muscle contractility ( J:131820 )

• isolated cardiomyocytes beat more slowly

• slower activation of currents in cardiomyocytes

• faster deactivation of currents in cardiomyocytes

Genotype
MGI:3776791

ht2

• Allelic Composition: Hcn4^tm1Rsei/Hcn4⁺
• Genetic Background: B6.Cg-Hcn4^tm1Rsei

cardiovascular system

decreased heart rate ( J:131820 )

• embryo heart rate fails to increase between E9.5 and E11.5 as it does in controls

• embryo heart rate is slower than in controls

• adult heart rate is similar to that of controls