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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hcn4tm1Rsei
targeted mutation 1, Reinhart Seifert
MGI:3775108
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hcn4tm1Rsei/Hcn4tm1Rsei B6.Cg-Hcn4tm1Rsei MGI:3776790
ht2
Hcn4tm1Rsei/Hcn4+ B6.Cg-Hcn4tm1Rsei MGI:3776791


Genotype
MGI:3776790
hm1
Allelic
Composition
Hcn4tm1Rsei/Hcn4tm1Rsei
Genetic
Background
B6.Cg-Hcn4tm1Rsei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcn4tm1Rsei mutation (1 available); any Hcn4 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes develop normally until E11 but are dead by E12

cardiovascular system
• isolated cardiomyocytes beat more slowly
• slower activation of currents in cardiomyocytes
• faster deactivation of currents in cardiomyocytes
• embryos display a reduced heart rate between E9.5 and E11.5
• superfusion of either isoproterenol or NKH477 fails to bring about an increase in heart rate

muscle
• isolated cardiomyocytes beat more slowly
• slower activation of currents in cardiomyocytes
• faster deactivation of currents in cardiomyocytes




Genotype
MGI:3776791
ht2
Allelic
Composition
Hcn4tm1Rsei/Hcn4+
Genetic
Background
B6.Cg-Hcn4tm1Rsei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcn4tm1Rsei mutation (1 available); any Hcn4 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• embryo heart rate fails to increase between E9.5 and E11.5 as it does in controls
• embryo heart rate is slower than in controls
• adult heart rate is similar to that of controls





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory