Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb7btm1Tani mutation
(1 available);
any
Zbtb7b mutation
(24 available)
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hematopoietic system
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• virtually all T cells found in the lymph node are double-positive T cells
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immune system
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• virtually all T cells found in the lymph node are double-positive T cells
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb7btm1Itan mutation
(0 available);
any
Zbtb7b mutation
(24 available)
Zbtb7btm1Tani mutation
(1 available);
any
Zbtb7b mutation
(24 available)
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immune system
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• the percentage of double negative thymocytes bearing Tcr-beta chains is doubled
• an unusual double negative T cell population is found in the lymph nodes of these mice
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• single positive CD8+ T cell numbers are increased in the thymus and lymph nodes
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• CD4+ T cells that express high levels of GFP have the ability to differentiate into CD8+ T cells in vitro
• CD4+ T cells that express high levels of GFP have the ability to differentiate into CD8+,or CD4+CD8+, or CD4-CD8- T cells when transferred into lymphocyte deficient hosts
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• single positive CD4+ T cell numbers are decreased in both in the thymus and lymph nodes
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• T-helper cells produce much less IL-4, have increased expression of IFN-gamma, and fail to express CD154 upon stimulation suggesting CD4 T cells from these mice have characteristics similar to CD8 T cells
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hematopoietic system
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• the percentage of double negative thymocytes bearing Tcr-beta chains is doubled
• an unusual double negative T cell population is found in the lymph nodes of these mice
|
|
• single positive CD8+ T cell numbers are increased in the thymus and lymph nodes
|
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• CD4+ T cells that express high levels of GFP have the ability to differentiate into CD8+ T cells in vitro
• CD4+ T cells that express high levels of GFP have the ability to differentiate into CD8+,or CD4+CD8+, or CD4-CD8- T cells when transferred into lymphocyte deficient hosts
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• single positive CD4+ T cell numbers are decreased in both in the thymus and lymph nodes
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• T-helper cells produce much less IL-4, have increased expression of IFN-gamma, and fail to express CD154 upon stimulation suggesting CD4 T cells from these mice have characteristics similar to CD8 T cells
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr96tm2Litt mutation
(0 available);
any
Rr96 mutation
(0 available)
Zbtb7btm1Tani mutation
(1 available);
any
Zbtb7b mutation
(24 available)
|
|
|
hematopoietic system
|
• virtually all T cells found in the lymph node are double-positive T cells
|
immune system
|
• virtually all T cells found in the lymph node are double-positive T cells
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr96tm2Litt mutation
(0 available);
any
Rr96 mutation
(0 available)
Zbtb7btm1Itan mutation
(0 available);
any
Zbtb7b mutation
(24 available)
Zbtb7btm1Tani mutation
(1 available);
any
Zbtb7b mutation
(24 available)
|
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immune system
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• the increase in double negative T cells observed in Zbtb7btm1Itan / Zbtb7btm1Tani compound heterozygotes is not observed in these mice
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• CD8+ T cells are almost absent in the periphery
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hematopoietic system
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• the increase in double negative T cells observed in Zbtb7btm1Itan / Zbtb7btm1Tani compound heterozygotes is not observed in these mice
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• CD8+ T cells are almost absent in the periphery
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