Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou5f1tm2Jae mutation
(1 available);
any
Pou5f1 mutation
(82 available)
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normal phenotype
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• mice are viable and fertile; some murine embryonic fibroblasts treated with specific transcription factors (Pou5f1, Sox2, c-myc, and Klf4) have the properties of induced pluripotent stem (iPS) cells. Such iPS cells have the DNA methylation, gene expression and chromatin state of embryonic stem cells and can form viable chimeras, contribute to the germ line, and generate live late-term embryos when injected into tetraploid blastocysts.
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac2tm1.1Eem mutation
(0 available);
any
Hdac2 mutation
(38 available)
Pou5f1tm2Jae mutation
(1 available);
any
Pou5f1 mutation
(82 available)
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cellular
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• mouse embryonic fibroblasts transduced with a cre-expressing adenovirus and a Mir302/367-expressing virus form Pou5f1-GFP+ produce viable induced pluripotent stem cells (iPSCs) unlike wild-type cells in the absence of valproic acid
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cellular
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• induced mouse embryonic fibroblasts exhibit a greater than 4-fold increase in reprogramming efficiency and generation of induced pluripotent stem cell compared with wild-type and Mir34atm1.1Ghan cells
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