Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fjx1tm1Awp mutation
(0 available);
any
Fjx1 mutation
(16 available)
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normal phenotype
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• mice exhibit no overt morphological abnormalities
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fat3tm1.2Good mutation
(0 available);
any
Fat3 mutation
(240 available)
Fjx1tm1Awp mutation
(0 available);
any
Fjx1 mutation
(16 available)
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vision/eye
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• no ectopic plexiform layers form and Bhlhb5+ amacrine cell distribution is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fat3tm1.2Good mutation
(0 available);
any
Fat3 mutation
(240 available)
Fjx1tm1Awp mutation
(0 available);
any
Fjx1 mutation
(16 available)
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vision/eye
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• mice exhibit a thin VGAT+ outer misplaced plexiform layer in the periphery of the ventral retina
• however, no inner misplaced plexiform layer forms
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fat4tm1.1Hmc mutation
(1 available);
any
Fat4 mutation
(223 available)
Fjx1tm1Awp mutation
(0 available);
any
Fjx1 mutation
(16 available)
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mortality/aging
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• fewer than expected mice are found at P0
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renal/urinary system
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• increase in the severity of cystic tubules compared to mice homozygous for Fat4tm1.1Hmc alone
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• in some cases cysts are so large that overall kidney size is dramatically increased
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• associated with enlarged kidneys
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• associated with enlarged kidneys
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• double ureter, associated with enlarged kidneys
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growth/size/body
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• increase in the severity of cystic tubules compared to mice homozygous for Fat4tm1.1Hmc alone
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• in some cases cysts are so large that overall kidney size is dramatically increased
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fjx1tm1Awp mutation
(0 available);
any
Fjx1 mutation
(16 available)
Tg(Thy1-YFP)HJrs mutation
(3 available)
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nervous system
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• dendritic trees of pyramidal cells in the CA1 region of the hippocampus are less complex than in wild-type mice
• the length of dendrites formed by granule cells in the dentate gyrus is increased (197+/-7 um compared to 164+/-7 um in wild-type mice)
• the complexity of apical dendrites in CA1 is reduced
• however, the complexity of granule cell dendrites in the dentate gyrus and the length of apical dendrites are normal
• in culture, dendrites of hippocampal neurons are 56% longer at day 3 and 88% longer at day 7 compared to wild-type neurons and the number of dendrites per cell is increased (1.8+/-0.2 compared to 1.2+/-0.1 for wild-type neurons) without affecting axon length, the number of axons per cell or the number of dendrites per cell
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fjx1tm1Awp mutation
(0 available);
any
Fjx1 mutation
(16 available)
Tg(Thy1-YFP)HJrs mutation
(3 available)
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nervous system
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• in culture, dendrites of hippocampal at day 7 are 50% longer compared to wild-type neurons
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Analysis Tools
