All Phenotypes Nbn<tm2.1Jpt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nbn^tm2.1Jpt
targeted mutation 2.1, John H Petrini
MGI:3771078

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nbn^tm2.1Jpt/Nbn^tm2.1Jpt	involves: 129	MGI:3771143
cx2	Lig4^tm1Icrf/Lig4^tm1Icrf Nbn^tm2.1Jpt/Nbn^tm2.1Jpt	involves: 129	MGI:3831186
cx3	Atm^tm1Awb/Atm^tm1Awb Nbn^tm2.1Jpt/Nbn^tm2.1Jpt	involves: 129S6/SvEvTac * 129/Sv	MGI:3771170
cx4	Nbn^tm2.1Jpt/Nbn^tm2.1Jpt Rad50^tm2Jpt/Rad50^tm2Jpt	involves: 129S7/SvEvBrd * 129/Sv	MGI:3771144
cx5	Nbn^tm2.1Jpt/Nbn⁺ Rad50^tm2Jpt/Rad50^tm2Jpt	involves: 129S7/SvEvBrd * 129/Sv	MGI:3771145

Allelic Composition	Nbn^tm2.1Jpt/Nbn^tm2.1Jpt
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbn^tm2.1Jpt mutation (0 available); any Nbn mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased cellular sensitivity to ionizing radiation ( J:129762 )

• following exposure to 10 Gy, mouse embryonic fibroblast cells exhibit a defect in the intra-S phase checkpoint and only 36% of cells suppress DNA synthesis compared to 51% of wild-type cells

• exposure to ionizing radiation results in a reduction of the apoptotic response in thymus cells compared to wild-type mice exhibit increased apoptosis in the thymus following exposure to ionizing radiation

• however, the distribution of thymocytes is normal

Allelic Composition	Lig4^tm1Icrf/Lig4^tm1Icrf Nbn^tm2.1Jpt/Nbn^tm2.1Jpt
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4^tm1Icrf mutation (0 available); any Lig4 mutation (44 available)
Nbn^tm2.1Jpt mutation (0 available); any Nbn mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:144172 )

• no live births are observed

Allelic Composition	Atm^tm1Awb/Atm^tm1Awb Nbn^tm2.1Jpt/Nbn^tm2.1Jpt
Genetic Background	involves: 129S6/SvEvTac * 129/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atm^tm1Awb mutation (7 available); any Atm mutation (169 available)
Nbn^tm2.1Jpt mutation (0 available); any Nbn mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased cellular sensitivity to ionizing radiation ( J:129762 )

• cells undergo fail to exhibit increased levels of apoptosis following exposure to ionizing radiation

Allelic Composition	Nbn^tm2.1Jpt/Nbn^tm2.1Jpt Rad50^tm2Jpt/Rad50^tm2Jpt
Genetic Background	involves: 129S7/SvEvBrd * 129/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbn^tm2.1Jpt mutation (0 available); any Nbn mutation (59 available)
Rad50^tm2Jpt mutation (0 available); any Rad50 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:129762 )

N	• unlike Rad50^tm2Jpt homozygotes, mice do not exhibit increased lethality or anemia at 8 months

cellular

decreased apoptosis ( J:129762 )

• attrition of B-, T- and myeloid cell lineages, gut and seminiferous tubules observed in Rad50^tm2Jpt homozygotes is mitigated

hematopoietic system

anemia ( J:129762 )

• compared to Rad50^tm2Jpt homozygotes, the age of onset of anemia is reduced

Allelic Composition	Nbn^tm2.1Jpt/Nbn⁺ Rad50^tm2Jpt/Rad50^tm2Jpt
Genetic Background	involves: 129S7/SvEvBrd * 129/Sv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:129762 )

N	• unlike Rad50^tm2Jpt homozygotes, mice do not exhibit increased lethality or anemia at 8 months

cellular

decreased apoptosis ( J:129762 )

• attrition of B-, T- and myeloid cell lineages, gut and seminiferous tubules observed in Rad50^tm2Jpt homozygotes is mitigated

hematopoietic system

anemia ( J:129762 )

• compared to Rad50^tm2Jpt homozygotes, the age of onset of anemia is reduced

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