Mouse Genome Informatics
hm1
    Nbntm2.1Jpt/Nbntm2.1Jpt
involves: 129/Sv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cellular
• following exposure to 10 Gy, mouse embryonic fibroblast cells exhibit a defect in the intra-S phase checkpoint and only 36% of cells suppress DNA synthesis compared to 51% of wild-type cells
• exposure to ionizing radiation results in a reduction of the apoptotic response in thymus cells compared to wild-type mice exhibit increased apoptosis in the thymus following exposure to ionizing radiation
• however, the distribution of thymocytes is normal


Mouse Genome Informatics
cx2
    Lig4tm1Icrf/Lig4tm1Icrf
Nbntm2.1Jpt/Nbntm2.1Jpt

involves: 129 * 129/Sv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• no live births are observed


Mouse Genome Informatics
cx3
    Atmtm1Awb/Atmtm1Awb
Nbntm2.1Jpt/Nbntm2.1Jpt

involves: 129S6/SvEvTac * 129/Sv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cellular
• cells undergo fail to exhibit increased levels of apoptosis following exposure to ionizing radiation


Mouse Genome Informatics
cx4
    Nbntm2.1Jpt/Nbntm2.1Jpt
Rad50tm2Jpt/Rad50tm2Jpt

involves: 129S7/SvEvBrd * 129/Sv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
N
• unlike Rad50tm2Jpt homozygotes, mice do not exhibit increased lethality or anemia at 8 months (J:129762)

cellular
• attrition of B-, T- and myeloid cell lineages, gut and seminiferous tubules observed in Rad50tm2Jpt homozygotes is mitigated

hematopoietic system
• compared to Rad50tm2Jpt homozygotes, the age of onset of anemia is reduced


Mouse Genome Informatics
cx5
    Nbntm2.1Jpt/Nbn+
Rad50tm2Jpt/Rad50tm2Jpt

involves: 129S7/SvEvBrd * 129/Sv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
N
• unlike Rad50tm2Jpt homozygotes, mice do not exhibit increased lethality or anemia at 8 months (J:129762)

cellular
• attrition of B-, T- and myeloid cell lineages, gut and seminiferous tubules observed in Rad50tm2Jpt homozygotes is mitigated

hematopoietic system
• compared to Rad50tm2Jpt homozygotes, the age of onset of anemia is reduced