Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef1tm1Djle mutation
(0 available);
any
Arhgef1 mutation
(73 available)
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immune system
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• in germinal centers when bone marrow cells are used to reconstitute wild-type mice
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hematopoietic system
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• in germinal centers when bone marrow cells are used to reconstitute wild-type mice
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef1tm1Djle mutation
(0 available);
any
Arhgef1 mutation
(73 available)
|
|
|
immune system
|
• the number of neutrophils and lymphocytes is increased 2-fold compared to in wild-type mice
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• when stimulated with formyl-peptide, neutrophils form and retract pseudopodia at inappropriate locations around the entire perimeter of the cell, migrate slower than wild-type neutrophils, and exhibit decreased adhesion
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hematopoietic system
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• in the red pulp of the spleen
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• the number of neutrophils and lymphocytes is increased 2-fold compared to in wild-type mice
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• when stimulated with formyl-peptide, neutrophils form and retract pseudopodia at inappropriate locations around the entire perimeter of the cell, migrate slower than wild-type neutrophils, and exhibit decreased adhesion
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growth/size/body