All Phenotypes Tg(PDGFB-GPR37)20Ryot MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(PDGFB-GPR37)20Ryot
transgene insertion 20, Ryosuke Takahashi
MGI:3768633

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Prkn^tm1Ykt/Prkn^tm1Ykt Tg(PDGFB-GPR37)20Ryot/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3814328
cx2	Prkn^tm1Ykt/Prkn^tm1Ykt Tg(PDGFB-GPR37)20Ryot/Tg(PDGFB-GPR37)20Ryot	involves: 129P2/OlaHsd * C57BL/6	MGI:3814330
tg3	Tg(PDGFB-GPR37)20Ryot/0	involves: C57BL/6	MGI:3768657

Allelic Composition	Prkn^tm1Ykt/Prkn^tm1Ykt Tg(PDGFB-GPR37)20Ryot/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkn^tm1Ykt mutation (0 available); any Prkn mutation (54 available)
Tg(PDGFB-GPR37)20Ryot mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

neuron degeneration ( J:140326 )

• at 18 months of age, mice exhibit a reduction in the number of TH+ or Nissl staining neurons in the substantia nigra pars compacta and locus ceruleus associated with apoptosis

behavior/neurological

behavior/neurological phenotype ( J:140326 )

N	• mice exhibit normal behaviors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 2		DOID:0060368	OMIM:600116	J:140326

Allelic Composition	Prkn^tm1Ykt/Prkn^tm1Ykt Tg(PDGFB-GPR37)20Ryot/Tg(PDGFB-GPR37)20Ryot
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkn^tm1Ykt mutation (0 available); any Prkn mutation (54 available)
Tg(PDGFB-GPR37)20Ryot mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

neuron degeneration ( J:140326 )

• at 12 months of age, mice exhibit a reduction in the number of TH+ or Nissl staining neurons in the substantia nigra pars compacta and locus ceruleus associated with apoptosis

behavior/neurological

behavior/neurological phenotype ( J:140326 )

N	• mice exhibit normal behaviors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 2		DOID:0060368	OMIM:600116	J:140326

Allelic Composition	Tg(PDGFB-GPR37)20Ryot/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:140326 )

N	• unlike other transgene lines over-expressing GPR37, mice do not exhibit dopaminergic neuron loss

behavior/neurological

hyperactivity ( J:128745 )

homeostasis/metabolism

increased dopamine level ( J:128745 )

• DOPAC and vesicular dopamine levels are increased in the striatum compared to in wild-type mice

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