Analysis Tools
nervous system
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• like wild-type neurons, cultured superior cervical ganglion neurons are resistant to apoptosis induced by pro-NGF and pro-BDNF
• however, pro-NGF and pro-BDNF induced apoptosis can be restored if neurons are treated with the intracellular domain of Ngfr
• sympathetic neurons survive the withdrawal of NGF better than wild-type neurons
• however, the number of sympathetic neurons is not increased
• unlike in wild-type mice, the number of superior cervical ganglion is not decreased at 60 weeks
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• unlike in wild-type mice, corticospinal motor neurons are protected from injury
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• at E15.5, the number of apoptotic cells is reduced by 63% compared to in wild-type mice
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vision/eye
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• at E15.5, the number of apoptotic cells is reduced by 63% compared to in wild-type mice
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