All Phenotypes Rapgef4<tm1.1Sse> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rapgef4^tm1.1Sse
targeted mutation 1.1, Susumu Seino
MGI:3767602

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rapgef4^tm1.1Sse/Rapgef4^tm1.1Sse	Not Specified	MGI:3767603

Allelic Composition	Rapgef4^tm1.1Sse/Rapgef4^tm1.1Sse
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rapgef4^tm1.1Sse mutation (0 available); any Rapgef4 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal insulin secretion ( J:128493 )

• insulin granule fusion stimulated by 8-Bromo-cAMP is reduced during the first phase of cAMP-dependent insulin granule exocytosis

• however, insulin granule fusion stimulated by glucose alone is normal

homeostasis/metabolism

abnormal insulin secretion ( J:128493 )

• insulin granule fusion stimulated by 8-Bromo-cAMP is reduced during the first phase of cAMP-dependent insulin granule exocytosis

• however, insulin granule fusion stimulated by glucose alone is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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