Phenotypes associated with this allele

• Allele Symbol: Bco1^tm1Dnp
• Allele Name: targeted mutation 1, Adrian Wyss
• Allele ID: MGI:3767552
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bco1^tm1Dnp/Bco1^tm1Dnp	involves: 129S6/SvEvTac * C57BL/6	MGI:3767556

Genotype
MGI:3767556

hm1

• Allelic Composition: Bco1^tm1Dnp/Bco1^tm1Dnp
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:128383 )

N • serum glucose, cholesterol ester, and triglyceride levels and glucose tolerance are all similar to wild-type controls

increased susceptibility to diet-induced obesity ( J:128383 )

• on a high fat diet mice gain significantly more weight compared to controls

increased circulating cholesterol level ( J:128383 )

• in mice on a high fat diet serum cholesterol ester levels are increased compared to controls

• however, on a standard diet serum cholesterol ester levels are similar to controls

increased circulating free fatty acids level ( J:128383 )

• at 28 weeks of age serum levels of unesterified free fatty acids are increased

• on a high fat diet the increase in serum free fatty acid level is larger than in diet-matched controls

increased circulating alanine transaminase level ( J:128383 )

• at 28 weeks of age serum levels of glutamate pyruvate transaminase are significantly increased compared to controls

abnormal vitamin homeostasis ( J:128383 )

• on a vitamin A deficient diet supplemented with beta-carotene (1000 ppm) visceral adipose tissue, subcutaneous adipose tissue, and the intestine show an orange coloring and accumulation of beta-carotene is detected in the intestine

• on a vitamin A deficient diet supplemented with beta-carotene (1000 ppm) about a 35-fold increase in beta-carotene blood levels is detected

• conversion of pro-vitamin to vitamin A is impaired

abnormal vitamin A level ( J:128383 )

• on a vitamin A deficient diet supplemented with beta-carotene (1000 ppm) tissue beta-carotene and vitamin A levels are increased and decreased, respectively, compared to wild-type controls in all tissues except the kidneys

• on a vitamin A sufficient diet liver vitamin A levels are similar to wild-type controls but serum beta-carotene levels are elevated and all-trans-retinol levels are slightly but significantly reduced

liver/biliary system

macrovesicular hepatic steatosis ( J:128383 )

• the liver contains more lipid and hepatocytes display large lipid droplets in mice on a vitamin A deficient diet supplemented with beta-carotene (1000 ppm)

• liver lipid accumulation is also seen in 3 month old mice on a vitamin A sufficient diet

• at 25 weeks of age livers contain significantly more total lipids and triglycerides in mice on a vitamin A sufficient diet

• on a high fat diet mice accumulate significantly more lipid in the liver and show more, larger lipid droplets in hepatocytes compared to controls

growth/size/body

increased susceptibility to diet-induced obesity ( J:128383 )

• on a high fat diet mice gain significantly more weight compared to controls