Phenotypes associated with this allele

• Allele Symbol: Tead2^tm1.1Mldp
• Allele Name: targeted mutation 1.1, Melvin DePamphilis
• Allele ID: MGI:3763367
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tead2^tm1.1Mldp/Tead2^tm1.1Mldp	involves: 129X1/SvJ * C57BL/6J * FVB/N	MGI:3763402
ht2	Tead2^tm1.1Mldp/Tead2^+	involves: 129X1/SvJ * C57BL/6J * FVB/N	MGI:3763406

Genotype
MGI:3763402

hm1

• Allelic Composition: Tead2^tm1.1Mldp/Tead2^tm1.1Mldp
• Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Exencephaly in Tead2^tm1.1Mldp/Tead2^tm1.1Mldp embryos at E13.5

mortality/aging

mortality/aging ( J:126338 , J:127233 )

N • mice survive into adulthood with no obvious morphological abnormalities (J:126338)

N • mice survive into adulthood (J:127233)

prenatal lethality, incomplete penetrance ( J:127233 )

• fewer than expected mice are born (19.7% compared to the expected 25%)

• however, surviving mice are viable, fertile and have no morphological abnormalities

nervous system

exencephaly ( J:127233 )

• 30% of mice exhibit exencephaly at E13.5

• exencephaly rates for mice produced from Tead2^tm1.1Mldp homozygous mothers is 5-fold greater than if only the father is homozygous for Tead2^tm1.1Mldp

• however, maternal folic acid supplementation reduced exencephaly rates by 3-fold

reproductive system

reproductive system phenotype ( J:127233 )

N • mice are fertile with normal follicular development

Genotype
MGI:3763406

ht2

• Allelic Composition: Tead2^tm1.1Mldp/Tead2⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

nervous system

exencephaly ( J:127233 )

• 6.25% to 7% of mice display exencephaly between E11.5 and E13.5