Phenotypes associated with this allele

• Allele Symbol: Ghrl^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3763213
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ghrl^tm1Lex/Ghrl^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:3763217

Genotype
MGI:3763217

hm1

• Allelic Composition: Ghrl^tm1Lex/Ghrl^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal food intake ( J:126636 )

• the optimal dose of ghrelin to stimulate food intake is 3.3-fold lower in homozygotes compared to wild-type controls

• artificial stimulation of feeding by turning the lights off for 6 hours during the light part of the day fails to increase food intake in old (50 - 65 weeks of age) mutant mice unlike in age-matched wild-type controls

• however, circadian patterns of spontaneous food intake are not significantly different from age matched controls in either young or old homozygotes

homeostasis/metabolism

decreased respiratory quotient ( J:126636 )

• during the dark but not the light period the respiratory quotient is significantly lower in young homozygotes compared to age-matched wild-type controls

• however, no difference is seen in old mice

abnormal metabolism ( J:126636 )

• heat production is significantly higher during both the light and dark period in young homozygotes compared to wild-type controls

• however, no difference is seen in old mice

digestive/alimentary system

digestive/alimentary phenotype ( J:126636 )

N • no significant difference is seen in gastric emptying despite expression patterns