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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Kiss1tm1Rla
targeted mutation 1, Risto Lapatto
MGI:3762755
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Kiss1tm1Rla/Kiss1tm1Rla involves: 129S1/SvImJ MGI:3762762


Genotype
MGI:3762762
hm1
Allelic
Composition
Kiss1tm1Rla/Kiss1tm1Rla
Genetic
Background
involves: 129S1/SvImJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kiss1tm1Rla mutation (0 available); any Kiss1 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• either absent or in greatly reduced numbers

reproductive system
• either absent or in greatly reduced numbers
• 13.1 + 1mm versus 17 + 2mm in wild-type mice
• this divergence first occurs in days 23-25 post birth
• bimodal distribution with half similar to wild-type, and half having an ovary weight 1/6th of normal
• occurs in female mice that also have persistent vaginal cornification
• half of the mice have persistent vaginal cornification upon vaginal opening
• difficult to detect
• difficult to detect
• reduced number of cells due to small small size of testis
• mean weight of 39.0 grams compared to 141.0 grams for wild-type mice
• occurs on average 10 days later than in wild-type mice
• absence of estrous cycling in 9-11 week old female mice
• unable to produce offspring with wild-type partners
• unable to produce offspring with wild-type partners

endocrine/exocrine glands
• difficult to detect
• difficult to detect
• bimodal distribution with half similar to wild-type, and half having an ovary weight 1/6th of normal
• occurs in female mice that also have persistent vaginal cornification
• reduced number of cells due to small small size of testis
• mean weight of 39.0 grams compared to 141.0 grams for wild-type mice

homeostasis/metabolism

digestive/alimentary system
• 13.1 + 1mm versus 17 + 2mm in wild-type mice
• this divergence first occurs in days 23-25 post birth

renal/urinary system
• difficult to detect

integument
• difficult to detect

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypogonadotropic hypogonadism 13 with or without anosmia DOID:0090073 OMIM:614842
J:126704





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory