Analysis Tools
reproductive system
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• at 4-5 months, epithelial cell lining of prostate tubules is disorganized, with tufting and/or cribriform growth patterns, unlike the regularly-layered columnar epithelial lining in controls
• epithelial cells are generally enlarged with some foci showing dysplasia characterized by cells with dense cytoplasm enlarged, somewhat vesicular nuclei with conspicuous nuclei
• at 7-9 months, distention of glands continues, with dysplasia becoming more diffuse
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• prostate lobes are obviously enlarged compared with control prostates; at 4-5 months, average weight is increased 2-fold and at 7-9 months increase is 3-fold
• at 14 months with prostate cancer, weight has rapidly increased
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• at 4-5 months of age, most glands of the different lobes show hyperplasia with accumulation of luminal cells, with distension of individual preexisting glands
• at 7-9 months hyperplasia continues to progress
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• progressive tumor development is observed in mice at 4-5 months along with focal prostatic intraepithelial neoplasia (PIN) lesions, 7-9 months with more widespread PIN and focal microinvasion and at 10-14 months with invasive tumors
• in 14-month old mice, tumors are all shown to be epithelial in origin, classified as adenocarcinoma of poor, low or moderate grade differentiation
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endocrine/exocrine glands
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• at 4-5 months, epithelial cell lining of prostate tubules is disorganized, with tufting and/or cribriform growth patterns, unlike the regularly-layered columnar epithelial lining in controls
• epithelial cells are generally enlarged with some foci showing dysplasia characterized by cells with dense cytoplasm enlarged, somewhat vesicular nuclei with conspicuous nuclei
• at 7-9 months, distention of glands continues, with dysplasia becoming more diffuse
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• prostate lobes are obviously enlarged compared with control prostates; at 4-5 months, average weight is increased 2-fold and at 7-9 months increase is 3-fold
• at 14 months with prostate cancer, weight has rapidly increased
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• at 4-5 months of age, most glands of the different lobes show hyperplasia with accumulation of luminal cells, with distension of individual preexisting glands
• at 7-9 months hyperplasia continues to progress
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• progressive tumor development is observed in mice at 4-5 months along with focal prostatic intraepithelial neoplasia (PIN) lesions, 7-9 months with more widespread PIN and focal microinvasion and at 10-14 months with invasive tumors
• in 14-month old mice, tumors are all shown to be epithelial in origin, classified as adenocarcinoma of poor, low or moderate grade differentiation
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neoplasm
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• progressive tumor development is observed in mice at 4-5 months along with focal prostatic intraepithelial neoplasia (PIN) lesions, 7-9 months with more widespread PIN and focal microinvasion and at 10-14 months with invasive tumors
• in 14-month old mice, tumors are all shown to be epithelial in origin, classified as adenocarcinoma of poor, low or moderate grade differentiation
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