All Phenotypes Diaph1<tm1.1Sna> MGI Mouse

Phenotypes associated with this allele

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal leukocyte migration ( J:126090 )

• CCL21-induced chemotaxis of double positive and single positive T cells is impaired

• egression of single positive thymocytes from the thymic lobes is decreased compared to in wild-type mice

• cell polarization and actin polymerization induced by chemokine stimulation is impaired compared to in wild-type mice

decreased T cell proliferation ( J:126090 )

• T cell proliferation in response to anti-CD3 antibodies and mixed lymphocyte reaction is impaired relative to in wild-type mice

decreased T cell number ( J:126090 )

• T cells are reduced in the blood, spleen and lymph nodes

• however, the number of B cells in the spleen and lymph nodes, and double positive, double negative and single positive thymocytes are normal

decreased CD4-positive, alpha-beta T cell number ( J:126090 )

• in the spleen and lymph nodes

decreased CD8-positive, alpha-beta T cell number ( J:126090 )

• in the spleen and lymph nodes

increased single-positive T cell number ( J:126090 )

• single positive CD4+CD8-, CD4-CD8+ and CD69^loCD62^hi thymocytes are increased

abnormal humoral immune response ( J:126090 )

• hapten-induced ear thickening elicited by dinitrofluorobenzene is impaired compared to that in similarly treated wild-type mice

hematopoietic system

abnormal leukocyte migration ( J:126090 )

• CCL21-induced chemotaxis of double positive and single positive T cells is impaired

• egression of single positive thymocytes from the thymic lobes is decreased compared to in wild-type mice

• cell polarization and actin polymerization induced by chemokine stimulation is impaired compared to in wild-type mice

decreased T cell proliferation ( J:126090 )

• T cell proliferation in response to anti-CD3 antibodies and mixed lymphocyte reaction is impaired relative to in wild-type mice

decreased T cell number ( J:126090 )

• T cells are reduced in the blood, spleen and lymph nodes

• however, the number of B cells in the spleen and lymph nodes, and double positive, double negative and single positive thymocytes are normal

decreased CD4-positive, alpha-beta T cell number ( J:126090 )

• in the spleen and lymph nodes

decreased CD8-positive, alpha-beta T cell number ( J:126090 )

• in the spleen and lymph nodes

increased single-positive T cell number ( J:126090 )

• single positive CD4+CD8-, CD4-CD8+ and CD69^loCD62^hi thymocytes are increased

cellular

abnormal leukocyte migration ( J:126090 )

• CCL21-induced chemotaxis of double positive and single positive T cells is impaired

• egression of single positive thymocytes from the thymic lobes is decreased compared to in wild-type mice

• cell polarization and actin polymerization induced by chemokine stimulation is impaired compared to in wild-type mice

decreased T cell proliferation ( J:126090 )

• T cell proliferation in response to anti-CD3 antibodies and mixed lymphocyte reaction is impaired relative to in wild-type mice

Allelic Composition	Diaph1^tm1.1Sna/Diaph1^tm1.1Sna Diaph2^tm1.2Sna/Diaph2^tm1.2Sna
Genetic Background	B6N.Cg-Diaph1^tm1.1Sna Diahp2^tm1.2Sna

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Diaph1^tm1.1Sna mutation (0 available); any Diaph1 mutation (116 available)
Diaph2^tm1.2Sna mutation (0 available); any Diaph2 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:215740 )

N	• layer formation in the somatosensory cortex is normal

abnormal neuronal migration ( J:215740 )

• fewer GAD65 and GAD67 positive cells enter the pallium and top of the cerebral cortex at E14.5 (impaired tangential migration of cortical inhibitory interneuron precursors)

• doublecortin positive subventricular zone cells at higher levels at the posterior of the rostral migratory stream than at the anterior end

• double cortin positive cells are disorganized on the lateral ventricle wall before migration

• migration of cells out of explants cultured in Matrigel is reduced

• migration of cells is slower

abnormal telencephalon morphology ( J:215740 )

abnormal cerebral cortex morphology ( J:215740 )

• fewer GABA cells in the cerebral cortex at E16.5

abnormal olfactory bulb morphology ( J:215740 )

abnormal olfactory bulb granule cell layer morphology ( J:215740 )

• marked loss of granule cells in adults

small olfactory bulb ( J:215740 )

• reduced in size whereas brain size is normal

cellular

abnormal neuronal migration ( J:215740 )

• fewer GAD65 and GAD67 positive cells enter the pallium and top of the cerebral cortex at E14.5 (impaired tangential migration of cortical inhibitory interneuron precursors)

• doublecortin positive subventricular zone cells at higher levels at the posterior of the rostral migratory stream than at the anterior end

• double cortin positive cells are disorganized on the lateral ventricle wall before migration

• migration of cells out of explants cultured in Matrigel is reduced

• migration of cells is slower

Allelic Composition	Diaph1^tm1.1Sna/Diaph1^tm1.1Sna Diaph2^tm1.2Sna/Y
Genetic Background	B6N.Cg-Diaph1^tm1.1Sna Diahp2^tm1.2Sna

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:215740 )

N	• layer formation in the somatosensory cortex is normal

abnormal neuronal migration ( J:215740 )

• fewer GAD65 and GAD67 positive cells enter the pallium and top of the cerebral cortex at E14.5 (impaired tangential migration of cortical inhibitory interneuron precursors)

• doublecortin positive subventricular zone cells at higher levels at the posterior of the rostral migratory stream than at the anterior end

• double cortin positive cells are disorganized on the lateral ventricle wall before migration

• migration of cells out of explants cultured in Matrigel is reduced

• migration of cells is slower

abnormal telencephalon morphology ( J:215740 )

abnormal cerebral cortex morphology ( J:215740 )

• fewer GABA cells in the cerebral cortex at E16.5

abnormal olfactory bulb morphology ( J:215740 )

abnormal olfactory bulb granule cell layer morphology ( J:215740 )

• marked loss of granule cells in adults

small olfactory bulb ( J:215740 )

• reduced in size whereas brain size is normal

cellular

abnormal neuronal migration ( J:215740 )

• fewer GAD65 and GAD67 positive cells enter the pallium and top of the cerebral cortex at E14.5 (impaired tangential migration of cortical inhibitory interneuron precursors)

• doublecortin positive subventricular zone cells at higher levels at the posterior of the rostral migratory stream than at the anterior end

• double cortin positive cells are disorganized on the lateral ventricle wall before migration

• migration of cells out of explants cultured in Matrigel is reduced

• migration of cells is slower

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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