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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(MMTV-neu/OT-I/OT-II)CBnel
transgene insertion C, Brad Nelson
MGI:3761163
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(MMTV-neu/OT-I/OT-II)CBnel/?
Tg(Trp53R172H)8512Jmr/?
involves: C57BL/6 * FVB MGI:3761175
tg2
Tg(MMTV-neu/OT-I/OT-II)CBnel/? involves: C57BL/6 MGI:3761174


Genotype
MGI:3761175
cx1
Allelic
Composition
Tg(MMTV-neu/OT-I/OT-II)CBnel/?
Tg(Trp53R172H)8512Jmr/?
Genetic
Background
involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-neu/OT-I/OT-II)CBnel mutation (1 available)
Tg(Trp53R172H)8512Jmr mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 80% of females develop adencarcinomas by 6-10 months of age; mice generally have 1or two tumors
• tumors are highly mitotic with glandular differentiation in ~30% of cases; ~90% of tumors have minimal necrosis

integument
• 80% of females develop adencarcinomas by 6-10 months of age; mice generally have 1or two tumors
• tumors are highly mitotic with glandular differentiation in ~30% of cases; ~90% of tumors have minimal necrosis

neoplasm
• 80% of females develop adencarcinomas by 6-10 months of age; mice generally have 1or two tumors
• tumors are highly mitotic with glandular differentiation in ~30% of cases; ~90% of tumors have minimal necrosis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:122846




Genotype
MGI:3761174
tg2
Allelic
Composition
Tg(MMTV-neu/OT-I/OT-II)CBnel/?
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-neu/OT-I/OT-II)CBnel mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• ~37% of mammary tumor-bearing mice frequently have lung metastases consisting of >1mm tumor cell emboli growing within blood vessels

endocrine/exocrine glands
• only ~50% of females develop mammary tumors by 16 months of age

integument
• only ~50% of females develop mammary tumors by 16 months of age

neoplasm
• only ~50% of females develop mammary tumors by 16 months of age
• ~37% of mammary tumor-bearing mice frequently have lung metastases consisting of >1mm tumor cell emboli growing within blood vessels

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:122846





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory