All Phenotypes Gnao1<tm1Adhi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gnao1^tm1Adhi
targeted mutation 1, Anuradha Dhingra
MGI:3759767

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gnao1^tm1Adhi/Gnao1^tm1Adhi	Not Specified	MGI:3759770

Allelic Composition	Gnao1^tm1Adhi/Gnao1^tm1Adhi
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnao1^tm1Adhi mutation (0 available); any Gnao1 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye electrophysiology ( J:125588 )

• under scotopic, saturated and photopic conditions mice lack the b-wave

• however, the a-wave is present under scotopic, saturated and photopic conditions

• under the saturated condition, mice produce a reduced a wave of 78+/-34 uV

abnormal cone electrophysiology ( J:125588 )

• under the photopic condition, the negative wave (a combination of a-wave and OFF bipolar response) is as large or greater than in wild-type mice

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