Phenotypes associated with this allele

• Allele Symbol: F10^tm1Ccmt
• Allele Name: targeted mutation 1, Katherine A High
• Allele ID: MGI:3759686
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	F10^tm1Ccmt/F10^tm1Ccmt	involves: 129P2/OlaHsd * C57BL/6	MGI:3841066
ht2	F10^tm1Ccmt/F10^tm2Ccmt	involves: 129P2/OlaHsd * C57BL/6	MGI:3841065

Genotype
MGI:3841066

hm1

• Allelic Composition: F10^tm1Ccmt/F10^tm1Ccmt
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality ( J:145092 )

• authors state that mice exhibit mortality similar to that observed in F10^tm1Edr homozygotes

embryonic lethality during organogenesis, incomplete penetrance ( J:145092 )

• fewer than expected mice are observed at E11.5 (14% compared to the expected 25%)

cardiovascular system

internal hemorrhage ( J:145092 )

• authors state that mice exhibit a pathology similar to that observed in F10^tm1Edr homozygotes

homeostasis/metabolism

increased bleeding time ( J:145092 )

• mice exhibit prolonged clot times compared to wild-type mice

Genotype
MGI:3841065

ht2

• Allelic Composition: F10^tm1Ccmt/F10^tm2Ccmt
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

reproductive system

decreased litter size ( J:145092 )

• female mice produce fewer F10^tm1Ccmt homozygous pups than female F10^tm1Ccmt heterozygotes