All Phenotypes Cdk4<tm2.1Bbd> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cdk4^tm2.1Bbd/Cdk4^tm2.1Bbd Kras^tm1Bbd/Kras^tm2Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd}	involves: 129S1/Sv * 129X1/SvJ	MGI:4844191
cn2	Cdk4^tm2.2Bbd/Cdk4^tm2.1Bbd Kras^tm1Bbd/Kras^tm2Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd}	involves: 129S1/Sv * 129X1/SvJ	MGI:4844192
cn3	Cdk2^tm2Sgo/Cdk2^tm2Sgo Cdk4^tm2.1Bbd/Cdk4^tm2.1Bbd Polr2a^{tm1(cre/ERT2)Bbd}/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3759577
cx4	Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk4^tm2.1Bbd/Cdk4^tm2.1Bbd	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL	MGI:3759575
cx5	Cdk2^tm1Sgo/Cdk2⁺ Cdk4^tm2.1Bbd/Cdk4⁺	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL	MGI:3759576

Allelic Composition	Cdk4^tm2.1Bbd/Cdk4^tm2.1Bbd Kras^tm1Bbd/Kras^tm2Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk4^tm2.1Bbd mutation (1 available); any Cdk4 mutation (57 available)
Kras^tm1Bbd mutation (2 available); any Kras mutation (76 available)
Kras^tm2Bbd mutation (0 available); any Kras mutation (76 available)
Polr2a^{tm1(cre/ERT2)Bbd} mutation (3 available); any Polr2a mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor growth/size ( J:161780 )

• lung cells in tamoxifen-treated mice exhibit 8- to 10-fold reduction in proliferation and early senescence compared to in similarly treated Kras^tm1Bbd/Kras^tm2Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} mice

increased adenocarcinoma incidence ( J:161780 )

• tamoxifen-treated mice exhibit adenocarcinomas that are not as severe as in Kras^tm1Bbd/Kras^tm2Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} mice

cellular

decreased cell proliferation ( J:161780 )

• proliferation of lung cells in tamoxifen-treated mice exhibit 8- to 10-fold less proliferation than in similarly treated Kras^tm1Bbd/Kras^tm2Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} mice

early cellular replicative senescence ( J:161780 )

• tamoxifen-treated mice exhibit increased cell replicative senescence in the lungs compared to in similarly treated Kras^tm1Bbd/Kras^tm2Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} mice

Allelic Composition	Cdk4^tm2.2Bbd/Cdk4^tm2.1Bbd Kras^tm1Bbd/Kras^tm2Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk4^tm2.1Bbd mutation (1 available); any Cdk4 mutation (57 available)
Cdk4^tm2.2Bbd mutation (0 available); any Cdk4 mutation (57 available)
Kras^tm1Bbd mutation (2 available); any Kras mutation (76 available)
Kras^tm2Bbd mutation (0 available); any Kras mutation (76 available)
Polr2a^{tm1(cre/ERT2)Bbd} mutation (3 available); any Polr2a mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor growth/size ( J:161780 )

• tamoxifen-treated mice infected with a flp-expressing adenovirus exhibit decreased proliferation and early senescence of tumor cells compared with tamoxifen and infected with GFP-expressing adenovirus

decreased tumor incidence ( J:161780 )

• tamoxifen-treated mice infected with a flp-expressing adenovirus exhibit reduced lesions compared to in mice treated with tamoxifen and infected with GFP-expressing adenovirus

increased tumor incidence ( J:161780 )

• in tamoxifen-treated mice as in similarly treated Kras^tm1Bbd/Kras^tm2Bbd Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} mice

cellular

decreased cell proliferation ( J:161780 )

• tamoxifen-treated mice infected with a flp-expressing adenovirus exhibit early senescence of tumor cells compared with tamoxifen and infected with GFP-expressing adenovirus

early cellular replicative senescence ( J:161780 )

• tamoxifen-treated mice infected with a flp-expressing adenovirus exhibit decreased proliferation of tumor cells compared with tamoxifen and infected with GFP-expressing adenovirus

Allelic Composition	Cdk2^tm2Sgo/Cdk2^tm2Sgo Cdk4^tm2.1Bbd/Cdk4^tm2.1Bbd Polr2a^{tm1(cre/ERT2)Bbd}/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2^tm2Sgo mutation (1 available); any Cdk2 mutation (17 available)
Cdk4^tm2.1Bbd mutation (1 available); any Cdk4 mutation (57 available)
Polr2a^{tm1(cre/ERT2)Bbd} mutation (3 available); any Polr2a mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:125217 )

• when 5 month old mice were treated with tamoxifen they exhibit reduced body size associated with the loss of the Cdk4 function

immune system

increased susceptibility to autoimmune diabetes ( J:125217 )

• when 5 month old mice were treated with tamoxifen they exhibit diabetes associated with the loss of the Cdk4 function

hematopoietic system

hematopoietic system phenotype ( J:125217 )

N	• adult hematopoiesis is normal following tamoxifen treatment at 5 months of age

liver/biliary system

liver/biliary system phenotype ( J:125217 )

N	• liver regeneration is normal following tamoxifen treatment at 5 months of age

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:125217 )

• although mice move and ingest milk at birth, they die within 24 hours due to cardiac failure

cardiovascular system

increased myocardial fiber size ( J:125217 )

• in some cases cardiomyocytes are hypertrophic and are partially disorganized by prominent capillaries

thin ventricular wall ( J:125217 )

• thin ventricular walls are associated with a one-third decrease in the number of proliferating cardiomyocytes

abnormal fetal cardiomyocyte proliferation ( J:125217 )

• thin ventricular walls are associated with a one-third decrease in the number of proliferating cardiomyocytes

congestive heart failure ( J:125217 )

• mice die within 24 hours of birth due to cardiac failure

liver/biliary system

liver hypoplasia ( J:125217 )

• fetal livers contain 60% of the cells found in wild-type livers

• however, this reduction is proportional to the reduction in overall size of embryos

• the number of hematopoietic cells in the fetal liver is reduced compared to in wild-type mice

abnormal liver physiology ( J:125217 )

• mice suffer from congestive livers

hematopoietic system

abnormal definitive hematopoiesis ( J:125217 )

• the number of hematopoietic cells in the fetal liver is reduced compared to in wild-type mice

• however, the number of granulocyte-macrophage progenitors, common myeloid progenitors and megakaryocyte-erythroid progenitor cells are normal

decreased erythrocyte cell number ( J:125217 )

• at E17.5, mice have a small decrease in red blood cell (RBC) number (1.27x10⁶+/-0.14 RBC per mm³ compared to 1.45x10⁶+/-0.11 RBC per mm³ in wild-type mice)

• however, this decrease does not affect viability

cellular

abnormal fetal cardiomyocyte proliferation ( J:125217 )

• thin ventricular walls are associated with a one-third decrease in the number of proliferating cardiomyocytes

abnormal cell cycle ( J:125217 )

• primary mouse embryonic fibroblast cells are delayed in the percent of cells entering into S phase but eventually equalize with wild-type cells

decreased fibroblast proliferation ( J:125217 )

• proliferation of mouse embryonic fibroblast (MEF) cells is decreased relative to wild-type MEFs

growth/size/body

decreased body weight ( J:125217 )

• at birth mice weigh 25% to 40% less than wild-type mice

muscle

increased myocardial fiber size ( J:125217 )

• in some cases cardiomyocytes are hypertrophic and are partially disorganized by prominent capillaries

abnormal fetal cardiomyocyte proliferation ( J:125217 )

• thin ventricular walls are associated with a one-third decrease in the number of proliferating cardiomyocytes

Allelic Composition	Cdk2^tm1Sgo/Cdk2⁺ Cdk4^tm2.1Bbd/Cdk4⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2^tm1Sgo mutation (1 available); any Cdk2 mutation (17 available)
Cdk4^tm2.1Bbd mutation (1 available); any Cdk4 mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryo development ( J:125217 )

• 60% of mice do not complete embryonic development

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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