Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm2.1Sud mutation
(1 available);
any
Nlgn3 mutation
(35 available)
Tg(Drd1-tdTomato)5Calak mutation
(1 available)
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nervous system
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• mice show a reduction of synaptic inhibition onto D1-dopamine receptor-expressing medium spiny neurons of the nucleus accumbens, with the miniature inhibitory postsynaptic current (mIPSC) frequency in the nucleus accumbens reduced by about 50%, whereas the mIPSC amplitude is unchanged
• however, no change in mIPSC frequency or amplitude is seen in D2-dopamine receptor-expressing medium spiny neurons and no change is seen in mIPSC frequency or amplitude in D1-dopamine receptor-expressing medium spiny neurons of the dorsal striatum
• spontaneous miniature excitatory postsynaptic currents (mEPSCs) from medium spiny neurons are normal, no changes in paired-pulse ratio of evoked EPSCs, and function of group I metabotropic glutamate receptors in medium spiny neurons of the nucleus acumbens is not altered
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Allelic Composition |
Nlgn3tm2.1Sud/Y
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Genetic Background |
involves: 129S1/Sv * 129X1/SvJ |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm2.1Sud mutation
(1 available);
any
Nlgn3 mutation
(35 available)
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behavior/neurological
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• mice exhibit increased learning rate but similar initial coordination on the accelerating rotarod
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• mice exhibit greater number of wall jumps
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• mice are hyperactive during open-field tests, showing increased total distance traveled and increased number of ambulatory episodes, however no changes in movement velocity or in crossings through the center of the open field are seen
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• mice show an abnormal bias in the direction of rotation during locomotion
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• mice perform similarly to wild-type littermates on the first trial of an accelerating rotarod, however in the last several trials, mice exhibit enhanced performance, with increased time on the rotarod before falling off compared to wild-type mice, indicating enhanced formation of repetitive motor routine
• the time spend performing stereotypic movements is enhanced during spontaneous open-field activity
• mice show increased vigor of stereotypic movements, indicated by greater force variance during periods of low mobility
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Allelic Composition |
Nlgn3tm2.1Sud/Y
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Genetic Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm2.1Sud mutation
(1 available);
any
Nlgn3 mutation
(35 available)
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normal phenotype
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• mice are viable, fertile, have no obvious abnormalities, and exhibit normal neurological and behavioral phenotypes
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