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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nlgn3tm2.1Sud
targeted mutation 2.1, Thomas C Sudhof
MGI:3758960
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Nlgn3tm2.1Sud/Y
Tg(Drd1-tdTomato)5Calak/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5660858
ot2
Nlgn3tm2.1Sud/Y involves: 129S1/Sv * 129X1/SvJ MGI:5660857
ot3
Nlgn3tm2.1Sud/Y involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3758962


Genotype
MGI:5660858
cx1
Allelic
Composition
Nlgn3tm2.1Sud/Y
Tg(Drd1-tdTomato)5Calak/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm2.1Sud mutation (1 available); any Nlgn3 mutation (21 available)
Tg(Drd1-tdTomato)5Calak mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice show a reduction of synaptic inhibition onto D1-dopamine receptor-expressing medium spiny neurons of the nucleus accumbens, with the miniature inhibitory postsynaptic current (mIPSC) frequency in the nucleus accumbens reduced by about 50%, whereas the mIPSC amplitude is unchanged
• however, no change in mIPSC frequency or amplitude is seen in D2-dopamine receptor-expressing medium spiny neurons and no change is seen in mIPSC frequency or amplitude in D1-dopamine receptor-expressing medium spiny neurons of the dorsal striatum
• spontaneous miniature excitatory postsynaptic currents (mEPSCs) from medium spiny neurons are normal, no changes in paired-pulse ratio of evoked EPSCs, and function of group I metabotropic glutamate receptors in medium spiny neurons of the nucleus acumbens is not altered




Genotype
MGI:5660857
ot2
Allelic
Composition
Nlgn3tm2.1Sud/Y
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm2.1Sud mutation (1 available); any Nlgn3 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit increased learning rate but similar initial coordination on the accelerating rotarod
• mice are hyperactive during open-field tests, showing increased total distance traveled and increased number of ambulatory episodes, however no changes in movement velocity or in crossings through the center of the open field are seen
• mice exhibit greater number of wall jumps
• mice show an abnormal bias in the direction of rotation during locomotion
• mice perform similarly to wild-type littermates on the first trial of an accelerating rotarod, however in the last several trials, mice exhibit enhanced performance, with increased time on the rotarod before falling off compared to wild-type mice, indicating enhanced formation of repetitive motor routine
• the time spend performing stereotypic movements is enhanced during spontaneous open-field activity
• mice show increased vigor of stereotypic movements, indicated by greater force variance during periods of low mobility




Genotype
MGI:3758962
ot3
Allelic
Composition
Nlgn3tm2.1Sud/Y
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm2.1Sud mutation (1 available); any Nlgn3 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable, fertile, have no obvious abnormalities, and exhibit normal neurological and behavioral phenotypes





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last database update
04/16/2019
MGI 6.13
The Jackson Laboratory